USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP28) has been implicated in tumourigenesis through it...

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Detalles Bibliográficos
Autores principales: Ruiz, E Josue, Pinto-Fernandez, Adan, Turnbull, Andrew P, Lan, Linxiang, Charlton, Thomas M, Scott, Hannah C, Damianou, Andreas, Vere, George, Riising, Eva M, Da Costa, Clive, Krajewski, Wojciech W, Guerin, David, Kearns, Jeffrey D, Ioannidis, Stephanos, Katz, Marie, McKinnon, Crystal, O'Connell, Jonathan, Moncaut, Natalia, Rosewell, Ian, Nye, Emma, Jones, Neil, Heride, Claire, Gersch, Malte, Wu, Min, Dinsmore, Christopher J, Hammonds, Tim R, Kim, Sunkyu, Komander, David, Urbe, Sylvie, Clague, Michael J, Kessler, Benedikt M, Behrens, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553340/
https://www.ncbi.nlm.nih.gov/pubmed/34636321
http://dx.doi.org/10.7554/eLife.71596

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