Effect of short-term exposure to air pollution on COVID-19 mortality and morbidity in Iranian cities

PURPOSE: The association between air pollutant (PM(2.5), PM(10), NO(2), and O(3)) concentrations and daily number of COVID-19 confirmed cases and related deaths were evaluated in three major Iranian cities (Tehran, Mashhad, and Tabriz). METHODS: Hourly concentrations of air pollutants and daily number of PCR-confirmed cases and deaths of COVID-19 were acquired (February 20(th), 2020 to January 4(th), 2021). A generalized additive model (GAM) assuming a quasi-Poisson distribution was used to model the associations in each city up to lag-day 7 (for mortality) and 14 (for morbidity). Then, the city-specific estimates were meta-analyzed using a fixed effect model to obtain the overall relative risks (RRs). RESULTS: A total of 114,964 confirmed cases and 21,549 deaths were recorded in these cities. For confirmed cases, exposure to PM(2.5), NO(2), and O(3) for several lag-days showed significant associations. In case of mortality, meta-analysis estimated that the RRs for PM(2.5), PM(10), NO(2), and O(3) concentrations were 1.06 (95% CI: 0.99, 1.13), 1.06 (95% CI: 0.93, 1.19), 1.15 (95% CI: 0.93, 1.38), and 1.07 (95% CI: 0.84, 1.31), respectively. Despite several positive associations with all air pollutants over multiple lag-days, COVID-19 mortality was only significantly associated with NO(2) on lag-days 0–1 and 1 with the RRs of 1.35 (95% CI: 1.04, 1.67) and 1.16 (95% CI: 1.02, 1.31), respectively. CONCLUSION: This study showed that air pollution can be a factor exacerbating COVID-19 infection and clinical outcomes. Actions should be taken to reduce the exposure of the public and particularly patients to ambient air pollutants. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40201-021-00736-4.