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Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia

Ibrutinib is a targeted therapy drug that blocks the activity of Bruton's tyrosine kinase, and it is an approved treatment for several mature B-cell malignancies including chronic lymphocytic leukaemia (CLL). Side effects include infections, cytopenia, nausea, and diarrhoea. In this report, we...

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Autores principales: Tjønnfjord, Sara Kristina Viberg, Tjønnfjord, Eirik Brekka, Konopski, Zbigniew, Tjønnfjord, Geir Erland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553503/
https://www.ncbi.nlm.nih.gov/pubmed/34721911
http://dx.doi.org/10.1155/2021/1862446
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author Tjønnfjord, Sara Kristina Viberg
Tjønnfjord, Eirik Brekka
Konopski, Zbigniew
Tjønnfjord, Geir Erland
author_facet Tjønnfjord, Sara Kristina Viberg
Tjønnfjord, Eirik Brekka
Konopski, Zbigniew
Tjønnfjord, Geir Erland
author_sort Tjønnfjord, Sara Kristina Viberg
collection PubMed
description Ibrutinib is a targeted therapy drug that blocks the activity of Bruton's tyrosine kinase, and it is an approved treatment for several mature B-cell malignancies including chronic lymphocytic leukaemia (CLL). Side effects include infections, cytopenia, nausea, and diarrhoea. In this report, we describe a case of hepatitis B reactivation in a female CLL patient undergoing treatment with ibrutinib. Diagnosis was confirmed with highly elevated hepatitis B virus DNA and a prior blood sample confirmed previous exposure. Ibrutinib was paused, and antiviral therapy was initiated with prompt clinical improvement. Ibrutinib was reinitiated shortly after clinical improvement. Thus, our case report demonstrates that systematic HBV screening is essential before starting treatment with ibrutinib. We suggest that antiviral prophylaxis is considered for patients at risk of reactivation, and ibrutinib may be continued following HBV reactivation with proper antiviral treatment.
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spelling pubmed-85535032021-10-29 Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia Tjønnfjord, Sara Kristina Viberg Tjønnfjord, Eirik Brekka Konopski, Zbigniew Tjønnfjord, Geir Erland Case Rep Hematol Case Report Ibrutinib is a targeted therapy drug that blocks the activity of Bruton's tyrosine kinase, and it is an approved treatment for several mature B-cell malignancies including chronic lymphocytic leukaemia (CLL). Side effects include infections, cytopenia, nausea, and diarrhoea. In this report, we describe a case of hepatitis B reactivation in a female CLL patient undergoing treatment with ibrutinib. Diagnosis was confirmed with highly elevated hepatitis B virus DNA and a prior blood sample confirmed previous exposure. Ibrutinib was paused, and antiviral therapy was initiated with prompt clinical improvement. Ibrutinib was reinitiated shortly after clinical improvement. Thus, our case report demonstrates that systematic HBV screening is essential before starting treatment with ibrutinib. We suggest that antiviral prophylaxis is considered for patients at risk of reactivation, and ibrutinib may be continued following HBV reactivation with proper antiviral treatment. Hindawi 2021-10-21 /pmc/articles/PMC8553503/ /pubmed/34721911 http://dx.doi.org/10.1155/2021/1862446 Text en Copyright © 2021 Sara Kristina Viberg Tjønnfjord et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tjønnfjord, Sara Kristina Viberg
Tjønnfjord, Eirik Brekka
Konopski, Zbigniew
Tjønnfjord, Geir Erland
Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia
title Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia
title_full Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia
title_fullStr Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia
title_full_unstemmed Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia
title_short Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia
title_sort successful control of hepatitis b virus reactivation following restart of ibrutinib in chronic lymphocytic leukaemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553503/
https://www.ncbi.nlm.nih.gov/pubmed/34721911
http://dx.doi.org/10.1155/2021/1862446
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