Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series

Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 olde...

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Autores principales: Chang, Cheng-Chen, Chen, Yen-Jen, Chen, Yu-An, Liao, Yi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553533/
https://www.ncbi.nlm.nih.gov/pubmed/34690134
http://dx.doi.org/10.9758/cpn.2021.19.4.789
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author Chang, Cheng-Chen
Chen, Yen-Jen
Chen, Yu-An
Liao, Yi-Cheng
author_facet Chang, Cheng-Chen
Chen, Yen-Jen
Chen, Yu-An
Liao, Yi-Cheng
author_sort Chang, Cheng-Chen
collection PubMed
description Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits.
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spelling pubmed-85535332021-11-30 Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series Chang, Cheng-Chen Chen, Yen-Jen Chen, Yu-An Liao, Yi-Cheng Clin Psychopharmacol Neurosci Case Report Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits. Korean College of Neuropsychopharmacology 2021-11-30 2021-11-30 /pmc/articles/PMC8553533/ /pubmed/34690134 http://dx.doi.org/10.9758/cpn.2021.19.4.789 Text en Copyright© 2021, Korean College of Neuropsychopharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chang, Cheng-Chen
Chen, Yen-Jen
Chen, Yu-An
Liao, Yi-Cheng
Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
title Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
title_full Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
title_fullStr Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
title_full_unstemmed Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
title_short Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
title_sort acute hepatitis due to agomelatine use in elderly women with depression: case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553533/
https://www.ncbi.nlm.nih.gov/pubmed/34690134
http://dx.doi.org/10.9758/cpn.2021.19.4.789
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AT liaoyicheng acutehepatitisduetoagomelatineuseinelderlywomenwithdepressioncaseseries

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