The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis

The conserved Argonaute-family members ALG-1 and ALG-2 are known to regulate processing and maturation of microRNAs to target mRNAs for degradation or translational inhibition (Bouasker and Simard 2012; Meister 2013). Consequently, depletion of alg-1 and alg-2 results in multiple phenotypes. Our dat...

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Detalles Bibliográficos
Autores principales: Finger, Fabian, Ottens, Franziska, Hoppe, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553546/
https://www.ncbi.nlm.nih.gov/pubmed/34723149
http://dx.doi.org/10.17912/micropub.biology.000457
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author Finger, Fabian
Ottens, Franziska
Hoppe, Thorsten
author_facet Finger, Fabian
Ottens, Franziska
Hoppe, Thorsten
author_sort Finger, Fabian
collection PubMed
description The conserved Argonaute-family members ALG-1 and ALG-2 are known to regulate processing and maturation of microRNAs to target mRNAs for degradation or translational inhibition (Bouasker and Simard 2012; Meister 2013). Consequently, depletion of alg-1 and alg-2 results in multiple phenotypes. Our data describe a role of microRNA-regulation in stress resistance and proteostasis with special emphasis on ubiquitin-dependent degradation pathways, such as ubiquitin fusion degradation (UFD) and endoplasmic reticulum (ER)-associated protein degradation (ERAD).
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spelling pubmed-85535462021-10-29 The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis Finger, Fabian Ottens, Franziska Hoppe, Thorsten MicroPubl Biol New Finding The conserved Argonaute-family members ALG-1 and ALG-2 are known to regulate processing and maturation of microRNAs to target mRNAs for degradation or translational inhibition (Bouasker and Simard 2012; Meister 2013). Consequently, depletion of alg-1 and alg-2 results in multiple phenotypes. Our data describe a role of microRNA-regulation in stress resistance and proteostasis with special emphasis on ubiquitin-dependent degradation pathways, such as ubiquitin fusion degradation (UFD) and endoplasmic reticulum (ER)-associated protein degradation (ERAD). Caltech Library 2021-10-14 /pmc/articles/PMC8553546/ /pubmed/34723149 http://dx.doi.org/10.17912/micropub.biology.000457 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Finger, Fabian
Ottens, Franziska
Hoppe, Thorsten
The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
title The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
title_full The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
title_fullStr The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
title_full_unstemmed The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
title_short The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
title_sort argonaute proteins alg-1 and alg-2 are linked to stress resistance and proteostasis
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553546/
https://www.ncbi.nlm.nih.gov/pubmed/34723149
http://dx.doi.org/10.17912/micropub.biology.000457
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