Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and Na(V)1.1 channels

Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage. However, the cellular origin and specific differential mechanisms are not clear. Increased glutamatergic activity is thought to be the key factor for generating cortical s...

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Detalles Bibliográficos
Autores principales: Chever, Oana, Zerimech, Sarah, Scalmani, Paolo, Lemaire, Louisiane, Pizzamiglio, Lara, Loucif, Alexandre, Ayrault, Marion, Krupa, Martin, Desroches, Mathieu, Duprat, Fabrice, Léna, Isabelle, Cestèle, Sandrine, Mantegazza, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553565/
https://www.ncbi.nlm.nih.gov/pubmed/34491914
http://dx.doi.org/10.1172/JCI142203

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