Potential of polygenic risk scores for improving population estimates of women’s breast cancer genetic risks

PURPOSE: Breast cancer risk has conventionally been assessed using family history (FH) and rare high/moderate penetrance pathogenic variants (PVs), notably in BRCA1/2, and more recently PALB2, CHEK2, and ATM. In addition to these PVs, it is now possible to use increasingly predictive polygenic risk...

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Detalles Bibliográficos
Autores principales: Wolfson, Michael, Gribble, Steve, Pashayan, Nora, Easton, Douglas F., Antoniou, Antonis C., Lee, Andrew, van Katwyk, Sasha, Simard, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553614/
https://www.ncbi.nlm.nih.gov/pubmed/34230637
http://dx.doi.org/10.1038/s41436-021-01258-y

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