The SARS-CoV-2 main protease M(pro) causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute respiratory s...

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Autores principales: Wenzel, Jan, Lampe, Josephine, Müller-Fielitz, Helge, Schuster, Raphael, Zille, Marietta, Müller, Kristin, Krohn, Markus, Körbelin, Jakob, Zhang, Linlin, Özorhan, Ümit, Neve, Vanessa, Wagner, Julian U. G., Bojkova, Denisa, Shumliakivska, Mariana, Jiang, Yun, Fähnrich, Anke, Ott, Fabian, Sencio, Valentin, Robil, Cyril, Pfefferle, Susanne, Sauve, Florent, Coêlho, Caio Fernando Ferreira, Franz, Jonas, Spiecker, Frauke, Lembrich, Beate, Binder, Sonja, Feller, Nina, König, Peter, Busch, Hauke, Collin, Ludovic, Villaseñor, Roberto, Jöhren, Olaf, Altmeppen, Hermann C., Pasparakis, Manolis, Dimmeler, Stefanie, Cinatl, Jindrich, Püschel, Klaus, Zelic, Matija, Ofengeim, Dimitry, Stadelmann, Christine, Trottein, François, Nogueiras, Ruben, Hilgenfeld, Rolf, Glatzel, Markus, Prevot, Vincent, Schwaninger, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553622/
https://www.ncbi.nlm.nih.gov/pubmed/34675436
http://dx.doi.org/10.1038/s41593-021-00926-1

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