Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil

We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in conval...

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Autores principales: Penetra, Stephanie L.S., da Silva, Michele F.B., Resende, Paola, Pina-Costa, Anielle, Santos, Heloisa F.P., Guaraldo, Lusiele, Calvet, Guilherme A., Ogrzewalska, Maria, Arantes, Ighor, Zukeram, Ketiuce, de Araújo, Mia F., Lima, Ana Beatriz Machado, Lopes, Renata Serrano, Lira-Silva, Larissa R., Moraes, Isabella V., Wakimoto, Mayumi D., Fuller, Trevon L., Gabaglia, Claudia Raja, Espíndola, Otávio M., Bonaldo, Myrna C., Daniel-Ribeiro, Cláudio Tadeu, Whitworth, Jimmy, Smith, Chris, Nielsen-Saines, Karin, Pauvolid-Correa, Alex, Siqueira, Marilda M., Brasil, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553653/
https://www.ncbi.nlm.nih.gov/pubmed/34757006
http://dx.doi.org/10.1016/j.ijid.2021.10.048
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author Penetra, Stephanie L.S.
da Silva, Michele F.B.
Resende, Paola
Pina-Costa, Anielle
Santos, Heloisa F.P.
Guaraldo, Lusiele
Calvet, Guilherme A.
Ogrzewalska, Maria
Arantes, Ighor
Zukeram, Ketiuce
de Araújo, Mia F.
Lima, Ana Beatriz Machado
Lopes, Renata Serrano
Lira-Silva, Larissa R.
Moraes, Isabella V.
Wakimoto, Mayumi D.
Fuller, Trevon L.
Gabaglia, Claudia Raja
Espíndola, Otávio M.
Bonaldo, Myrna C.
Daniel-Ribeiro, Cláudio Tadeu
Whitworth, Jimmy
Smith, Chris
Nielsen-Saines, Karin
Pauvolid-Correa, Alex
Siqueira, Marilda M.
Brasil, Patricia
author_facet Penetra, Stephanie L.S.
da Silva, Michele F.B.
Resende, Paola
Pina-Costa, Anielle
Santos, Heloisa F.P.
Guaraldo, Lusiele
Calvet, Guilherme A.
Ogrzewalska, Maria
Arantes, Ighor
Zukeram, Ketiuce
de Araújo, Mia F.
Lima, Ana Beatriz Machado
Lopes, Renata Serrano
Lira-Silva, Larissa R.
Moraes, Isabella V.
Wakimoto, Mayumi D.
Fuller, Trevon L.
Gabaglia, Claudia Raja
Espíndola, Otávio M.
Bonaldo, Myrna C.
Daniel-Ribeiro, Cláudio Tadeu
Whitworth, Jimmy
Smith, Chris
Nielsen-Saines, Karin
Pauvolid-Correa, Alex
Siqueira, Marilda M.
Brasil, Patricia
author_sort Penetra, Stephanie L.S.
collection PubMed
description We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.
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spelling pubmed-85536532021-10-29 Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil Penetra, Stephanie L.S. da Silva, Michele F.B. Resende, Paola Pina-Costa, Anielle Santos, Heloisa F.P. Guaraldo, Lusiele Calvet, Guilherme A. Ogrzewalska, Maria Arantes, Ighor Zukeram, Ketiuce de Araújo, Mia F. Lima, Ana Beatriz Machado Lopes, Renata Serrano Lira-Silva, Larissa R. Moraes, Isabella V. Wakimoto, Mayumi D. Fuller, Trevon L. Gabaglia, Claudia Raja Espíndola, Otávio M. Bonaldo, Myrna C. Daniel-Ribeiro, Cláudio Tadeu Whitworth, Jimmy Smith, Chris Nielsen-Saines, Karin Pauvolid-Correa, Alex Siqueira, Marilda M. Brasil, Patricia Int J Infect Dis Case Report We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022-01 2021-10-29 /pmc/articles/PMC8553653/ /pubmed/34757006 http://dx.doi.org/10.1016/j.ijid.2021.10.048 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Penetra, Stephanie L.S.
da Silva, Michele F.B.
Resende, Paola
Pina-Costa, Anielle
Santos, Heloisa F.P.
Guaraldo, Lusiele
Calvet, Guilherme A.
Ogrzewalska, Maria
Arantes, Ighor
Zukeram, Ketiuce
de Araújo, Mia F.
Lima, Ana Beatriz Machado
Lopes, Renata Serrano
Lira-Silva, Larissa R.
Moraes, Isabella V.
Wakimoto, Mayumi D.
Fuller, Trevon L.
Gabaglia, Claudia Raja
Espíndola, Otávio M.
Bonaldo, Myrna C.
Daniel-Ribeiro, Cláudio Tadeu
Whitworth, Jimmy
Smith, Chris
Nielsen-Saines, Karin
Pauvolid-Correa, Alex
Siqueira, Marilda M.
Brasil, Patricia
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
title Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
title_full Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
title_fullStr Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
title_full_unstemmed Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
title_short Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
title_sort post-acute covid-19 syndrome after reinfection and vaccine breakthrough by the sars-cov-2 gamma variant in brazil
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553653/
https://www.ncbi.nlm.nih.gov/pubmed/34757006
http://dx.doi.org/10.1016/j.ijid.2021.10.048
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