COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days....

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Detalles Bibliográficos
Autores principales: Leung, Wayne F., Chorlton, Samuel, Tyson, John, Al-Rawahi, Ghada N., Jassem, Agatha N., Prystajecky, Natalie, Masud, Shazia, Deans, Gregory D., Chapman, Michael G., Mirzanejad, Yazdan, Murray, Melanie C.M., Wong, Patrick H.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553657/
https://www.ncbi.nlm.nih.gov/pubmed/34757008
http://dx.doi.org/10.1016/j.ijid.2021.10.045
Descripción
Sumario:This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.

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