COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days....

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Autores principales: Leung, Wayne F., Chorlton, Samuel, Tyson, John, Al-Rawahi, Ghada N., Jassem, Agatha N., Prystajecky, Natalie, Masud, Shazia, Deans, Gregory D., Chapman, Michael G., Mirzanejad, Yazdan, Murray, Melanie C.M., Wong, Patrick H.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553657/
https://www.ncbi.nlm.nih.gov/pubmed/34757008
http://dx.doi.org/10.1016/j.ijid.2021.10.045
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author Leung, Wayne F.
Chorlton, Samuel
Tyson, John
Al-Rawahi, Ghada N.
Jassem, Agatha N.
Prystajecky, Natalie
Masud, Shazia
Deans, Gregory D.
Chapman, Michael G.
Mirzanejad, Yazdan
Murray, Melanie C.M.
Wong, Patrick H.P.
author_facet Leung, Wayne F.
Chorlton, Samuel
Tyson, John
Al-Rawahi, Ghada N.
Jassem, Agatha N.
Prystajecky, Natalie
Masud, Shazia
Deans, Gregory D.
Chapman, Michael G.
Mirzanejad, Yazdan
Murray, Melanie C.M.
Wong, Patrick H.P.
author_sort Leung, Wayne F.
collection PubMed
description This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.
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spelling pubmed-85536572021-10-29 COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report Leung, Wayne F. Chorlton, Samuel Tyson, John Al-Rawahi, Ghada N. Jassem, Agatha N. Prystajecky, Natalie Masud, Shazia Deans, Gregory D. Chapman, Michael G. Mirzanejad, Yazdan Murray, Melanie C.M. Wong, Patrick H.P. Int J Infect Dis Article This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022-01 2021-10-29 /pmc/articles/PMC8553657/ /pubmed/34757008 http://dx.doi.org/10.1016/j.ijid.2021.10.045 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Leung, Wayne F.
Chorlton, Samuel
Tyson, John
Al-Rawahi, Ghada N.
Jassem, Agatha N.
Prystajecky, Natalie
Masud, Shazia
Deans, Gregory D.
Chapman, Michael G.
Mirzanejad, Yazdan
Murray, Melanie C.M.
Wong, Patrick H.P.
COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_full COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_fullStr COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_full_unstemmed COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_short COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_sort covid-19 in an immunocompromised host: persistent shedding of viable sars-cov-2 and emergence of multiple mutations: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553657/
https://www.ncbi.nlm.nih.gov/pubmed/34757008
http://dx.doi.org/10.1016/j.ijid.2021.10.045
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