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Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics
Mesenchymal stromal/stem cells (MSCs) are a unique population of cells that play an important role in the regeneration potential of the body. MSCs exhibit a characteristic phenotype and are capable of modulating the immune response. MSCs can be isolated from various tissues such as: bone marrow, adi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553697/ https://www.ncbi.nlm.nih.gov/pubmed/33860454 http://dx.doi.org/10.1007/s12015-021-10157-3 |
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author | Semenova, Ekaterina Grudniak, Mariusz P Machaj, Eugeniusz K Bocian, Katarzyna Chroscinska-Krawczyk, Magdalena Trochonowicz, Marzena Stepaniec, Igor M Murzyn, Magdalena Zagorska, Karolina E Boruczkowski, Dariusz Kolanowski, Tomasz J Oldak, Tomasz Rozwadowska, Natalia |
author_facet | Semenova, Ekaterina Grudniak, Mariusz P Machaj, Eugeniusz K Bocian, Katarzyna Chroscinska-Krawczyk, Magdalena Trochonowicz, Marzena Stepaniec, Igor M Murzyn, Magdalena Zagorska, Karolina E Boruczkowski, Dariusz Kolanowski, Tomasz J Oldak, Tomasz Rozwadowska, Natalia |
author_sort | Semenova, Ekaterina |
collection | PubMed |
description | Mesenchymal stromal/stem cells (MSCs) are a unique population of cells that play an important role in the regeneration potential of the body. MSCs exhibit a characteristic phenotype and are capable of modulating the immune response. MSCs can be isolated from various tissues such as: bone marrow, adipose tissue, placenta, umbilical cord and others. The umbilical cord as a source of MSCs, has strong advantages, such as no-risk procedure of tissue retrieval after birth and easiness of the MSCs isolation. As the umbilical cord (UC) is a complex organ and we decided to evaluate, whether the cells derived from different regions of umbilical cord show similar or distinct properties. In this study we characterized and compared MSCs from three regions of the umbilical cord: Wharton’s Jelly (WJ), the perivascular space (PRV) and the umbilical membrane (UCM). The analysis was carried out in terms of morphology, phenotype, immunomodulation potential and secretome. Based on the obtained results, we were able to conclude, that MSCs derived from distinct UC regions differ in their properties. According to our result WJ-MSCs have high and stabile proliferation potential and phenotype, when compare with other MSCs and can be treated as a preferable source of cells for medical application. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-8553697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-85536972021-11-04 Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics Semenova, Ekaterina Grudniak, Mariusz P Machaj, Eugeniusz K Bocian, Katarzyna Chroscinska-Krawczyk, Magdalena Trochonowicz, Marzena Stepaniec, Igor M Murzyn, Magdalena Zagorska, Karolina E Boruczkowski, Dariusz Kolanowski, Tomasz J Oldak, Tomasz Rozwadowska, Natalia Stem Cell Rev Rep Article Mesenchymal stromal/stem cells (MSCs) are a unique population of cells that play an important role in the regeneration potential of the body. MSCs exhibit a characteristic phenotype and are capable of modulating the immune response. MSCs can be isolated from various tissues such as: bone marrow, adipose tissue, placenta, umbilical cord and others. The umbilical cord as a source of MSCs, has strong advantages, such as no-risk procedure of tissue retrieval after birth and easiness of the MSCs isolation. As the umbilical cord (UC) is a complex organ and we decided to evaluate, whether the cells derived from different regions of umbilical cord show similar or distinct properties. In this study we characterized and compared MSCs from three regions of the umbilical cord: Wharton’s Jelly (WJ), the perivascular space (PRV) and the umbilical membrane (UCM). The analysis was carried out in terms of morphology, phenotype, immunomodulation potential and secretome. Based on the obtained results, we were able to conclude, that MSCs derived from distinct UC regions differ in their properties. According to our result WJ-MSCs have high and stabile proliferation potential and phenotype, when compare with other MSCs and can be treated as a preferable source of cells for medical application. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2021-04-15 2021 /pmc/articles/PMC8553697/ /pubmed/33860454 http://dx.doi.org/10.1007/s12015-021-10157-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Semenova, Ekaterina Grudniak, Mariusz P Machaj, Eugeniusz K Bocian, Katarzyna Chroscinska-Krawczyk, Magdalena Trochonowicz, Marzena Stepaniec, Igor M Murzyn, Magdalena Zagorska, Karolina E Boruczkowski, Dariusz Kolanowski, Tomasz J Oldak, Tomasz Rozwadowska, Natalia Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics |
title | Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics |
title_full | Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics |
title_fullStr | Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics |
title_full_unstemmed | Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics |
title_short | Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics |
title_sort | mesenchymal stromal cells from different parts of umbilical cord: approach to comparison & characteristics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553697/ https://www.ncbi.nlm.nih.gov/pubmed/33860454 http://dx.doi.org/10.1007/s12015-021-10157-3 |
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