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The effect of clamped and unclamped umbilical cord samples on blood gas analysis

PURPOSE: Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s...

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Autores principales: Colciago, Elisabetta, Fumagalli, Simona, Ciarmoli, Elena, Antolini, Laura, Nespoli, Antonella, Mastrolia, Salvatore Andrea, Tagliabue, Paolo Emilio, Furlan, Chiara, Manganini, Cristina, Vergani, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553729/
https://www.ncbi.nlm.nih.gov/pubmed/34021806
http://dx.doi.org/10.1007/s00404-021-06076-w
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author Colciago, Elisabetta
Fumagalli, Simona
Ciarmoli, Elena
Antolini, Laura
Nespoli, Antonella
Mastrolia, Salvatore Andrea
Tagliabue, Paolo Emilio
Furlan, Chiara
Manganini, Cristina
Vergani, Patrizia
author_facet Colciago, Elisabetta
Fumagalli, Simona
Ciarmoli, Elena
Antolini, Laura
Nespoli, Antonella
Mastrolia, Salvatore Andrea
Tagliabue, Paolo Emilio
Furlan, Chiara
Manganini, Cristina
Vergani, Patrizia
author_sort Colciago, Elisabetta
collection PubMed
description PURPOSE: Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups. METHODS: A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped). RESULTS: There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group. CONCLUSION: Samples from the unclamped cord alter the acid–base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed.
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spelling pubmed-85537292021-11-04 The effect of clamped and unclamped umbilical cord samples on blood gas analysis Colciago, Elisabetta Fumagalli, Simona Ciarmoli, Elena Antolini, Laura Nespoli, Antonella Mastrolia, Salvatore Andrea Tagliabue, Paolo Emilio Furlan, Chiara Manganini, Cristina Vergani, Patrizia Arch Gynecol Obstet Maternal-Fetal Medicine PURPOSE: Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups. METHODS: A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped). RESULTS: There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group. CONCLUSION: Samples from the unclamped cord alter the acid–base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed. Springer Berlin Heidelberg 2021-05-22 2021 /pmc/articles/PMC8553729/ /pubmed/34021806 http://dx.doi.org/10.1007/s00404-021-06076-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Maternal-Fetal Medicine
Colciago, Elisabetta
Fumagalli, Simona
Ciarmoli, Elena
Antolini, Laura
Nespoli, Antonella
Mastrolia, Salvatore Andrea
Tagliabue, Paolo Emilio
Furlan, Chiara
Manganini, Cristina
Vergani, Patrizia
The effect of clamped and unclamped umbilical cord samples on blood gas analysis
title The effect of clamped and unclamped umbilical cord samples on blood gas analysis
title_full The effect of clamped and unclamped umbilical cord samples on blood gas analysis
title_fullStr The effect of clamped and unclamped umbilical cord samples on blood gas analysis
title_full_unstemmed The effect of clamped and unclamped umbilical cord samples on blood gas analysis
title_short The effect of clamped and unclamped umbilical cord samples on blood gas analysis
title_sort effect of clamped and unclamped umbilical cord samples on blood gas analysis
topic Maternal-Fetal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553729/
https://www.ncbi.nlm.nih.gov/pubmed/34021806
http://dx.doi.org/10.1007/s00404-021-06076-w
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