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Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

Presence of TGFβ in the tumor microenvironment is one of the most relevant cancer immune-escape mechanisms. TGFβ is secreted in an inactive form, and its activation within the tumor may depend on different cell types and mechanisms than its production. Here we show in mouse melanoma and breast cance...

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Detalles Bibliográficos
Autores principales:	Lainé, Alexandra, Labiad, Ossama, Hernandez-Vargas, Hector, This, Sébastien, Sanlaville, Amélien, Léon, Sophie, Dalle, Stéphane, Sheppard, Dean, Travis, Mark A., Paidassi, Helena, Marie, Julien C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553942/ https://www.ncbi.nlm.nih.gov/pubmed/34711823 http://dx.doi.org/10.1038/s41467-021-26352-2

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