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Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model

Accurately identifying epileptogenic zone (EZ) using high-frequency oscillations (HFOs) is a challenge that must be mastered to transfer HFOs into clinical use. We analyzed the ability of a convolutional neural network (CNN) model to distinguish EZ and non-EZ HFOs. Nineteen medically intractable epi...

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Autores principales: Ren, Guoping, Sun, Yueqian, Wang, Dan, Ren, Jiechuan, Dai, Jindong, Mei, Shanshan, Li, Yunlin, Wang, Xiaofei, Yang, Xiaofeng, Yan, Jiaqing, Wang, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553964/
https://www.ncbi.nlm.nih.gov/pubmed/34721249
http://dx.doi.org/10.3389/fneur.2021.640526
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author Ren, Guoping
Sun, Yueqian
Wang, Dan
Ren, Jiechuan
Dai, Jindong
Mei, Shanshan
Li, Yunlin
Wang, Xiaofei
Yang, Xiaofeng
Yan, Jiaqing
Wang, Qun
author_facet Ren, Guoping
Sun, Yueqian
Wang, Dan
Ren, Jiechuan
Dai, Jindong
Mei, Shanshan
Li, Yunlin
Wang, Xiaofei
Yang, Xiaofeng
Yan, Jiaqing
Wang, Qun
author_sort Ren, Guoping
collection PubMed
description Accurately identifying epileptogenic zone (EZ) using high-frequency oscillations (HFOs) is a challenge that must be mastered to transfer HFOs into clinical use. We analyzed the ability of a convolutional neural network (CNN) model to distinguish EZ and non-EZ HFOs. Nineteen medically intractable epilepsy patients with good surgical outcomes 2 years after surgery were studied. Five-minute interictal intracranial electroencephalogram epochs of slow-wave sleep were selected randomly. Then 5 s segments of ripples (80–200 Hz) and fast ripples (FRs, 200–500 Hz) were detected automatically. The EZs and non-EZs were identified using the surgery resection range. We innovatively converted all epochs into four types of images using two scales: original waveforms, filtered waveforms, wavelet spectrum images, and smoothed pseudo Wigner–Ville distribution (SPWVD) spectrum images. Two scales were fixed and fitted scales. We then used a CNN model to classify the HFOs into EZ and non-EZ categories. As a result, 7,000 epochs of ripples and 2,000 epochs of FRs were randomly selected from the EZ and non-EZ data for analysis. Our CNN model can distinguish EZ and non-EZ HFOs successfully. Except for original ripple waveforms, the results from CNN models that are trained using fixed-scale images are significantly better than those from models trained using fitted-scale images (p < 0.05). Of the four fixed-scale transformations, the CNN based on the adjusted SPWVD (ASPWVD) produced the best accuracies (80.89 ± 1.43% and 77.85 ± 1.61% for ripples and FRs, respectively, p < 0.05). The CNN using ASPWVD transformation images is an effective deep learning method that can be used to classify EZ and non-EZ HFOs.
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spelling pubmed-85539642021-10-30 Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model Ren, Guoping Sun, Yueqian Wang, Dan Ren, Jiechuan Dai, Jindong Mei, Shanshan Li, Yunlin Wang, Xiaofei Yang, Xiaofeng Yan, Jiaqing Wang, Qun Front Neurol Neurology Accurately identifying epileptogenic zone (EZ) using high-frequency oscillations (HFOs) is a challenge that must be mastered to transfer HFOs into clinical use. We analyzed the ability of a convolutional neural network (CNN) model to distinguish EZ and non-EZ HFOs. Nineteen medically intractable epilepsy patients with good surgical outcomes 2 years after surgery were studied. Five-minute interictal intracranial electroencephalogram epochs of slow-wave sleep were selected randomly. Then 5 s segments of ripples (80–200 Hz) and fast ripples (FRs, 200–500 Hz) were detected automatically. The EZs and non-EZs were identified using the surgery resection range. We innovatively converted all epochs into four types of images using two scales: original waveforms, filtered waveforms, wavelet spectrum images, and smoothed pseudo Wigner–Ville distribution (SPWVD) spectrum images. Two scales were fixed and fitted scales. We then used a CNN model to classify the HFOs into EZ and non-EZ categories. As a result, 7,000 epochs of ripples and 2,000 epochs of FRs were randomly selected from the EZ and non-EZ data for analysis. Our CNN model can distinguish EZ and non-EZ HFOs successfully. Except for original ripple waveforms, the results from CNN models that are trained using fixed-scale images are significantly better than those from models trained using fitted-scale images (p < 0.05). Of the four fixed-scale transformations, the CNN based on the adjusted SPWVD (ASPWVD) produced the best accuracies (80.89 ± 1.43% and 77.85 ± 1.61% for ripples and FRs, respectively, p < 0.05). The CNN using ASPWVD transformation images is an effective deep learning method that can be used to classify EZ and non-EZ HFOs. Frontiers Media S.A. 2021-10-15 /pmc/articles/PMC8553964/ /pubmed/34721249 http://dx.doi.org/10.3389/fneur.2021.640526 Text en Copyright © 2021 Ren, Sun, Wang, Ren, Dai, Mei, Li, Wang, Yang, Yan and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Ren, Guoping
Sun, Yueqian
Wang, Dan
Ren, Jiechuan
Dai, Jindong
Mei, Shanshan
Li, Yunlin
Wang, Xiaofei
Yang, Xiaofeng
Yan, Jiaqing
Wang, Qun
Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model
title Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model
title_full Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model
title_fullStr Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model
title_full_unstemmed Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model
title_short Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model
title_sort identification of epileptogenic and non-epileptogenic high-frequency oscillations using a multi-feature convolutional neural network model
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553964/
https://www.ncbi.nlm.nih.gov/pubmed/34721249
http://dx.doi.org/10.3389/fneur.2021.640526
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