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Lab-to-Field Transition of RNA Spray Applications – How Far Are We?

The drastic loss of biodiversity has alarmed the public and raised sociopolitical demand for chemical pesticide-free plant production, which is now treated by governments worldwide as a top priority. Given this global challenge, RNAi-based technologies are rapidly evolving as a promising substitute...

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Detalles Bibliográficos
Autores principales: Rank, Aline Pereira, Koch, Aline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554022/
https://www.ncbi.nlm.nih.gov/pubmed/34721485
http://dx.doi.org/10.3389/fpls.2021.755203
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author Rank, Aline Pereira
Koch, Aline
author_facet Rank, Aline Pereira
Koch, Aline
author_sort Rank, Aline Pereira
collection PubMed
description The drastic loss of biodiversity has alarmed the public and raised sociopolitical demand for chemical pesticide-free plant production, which is now treated by governments worldwide as a top priority. Given this global challenge, RNAi-based technologies are rapidly evolving as a promising substitute to conventional chemical pesticides. Primarily, genetically modified (GM) crops expressing double-stranded (ds)RNA-mediating gene silencing of foreign transcripts have been developed. However, since the cultivation of GM RNAi crops is viewed negatively in numerous countries, GM-free exogenous RNA spray applications attract tremendous scientific and political interest. The sudden rise in demand for pesticide alternatives has boosted research on sprayable RNA biopesticides, generating significant technological developments and advancing the potential for field applications in the near future. Here we review the latest advances that could pave the way for a quick lab-to-field transition for RNA sprays, which, as safe, selective, broadly applicable, and cost-effective biopesticides, represent an innovation in sustainable crop production. Given these latest advances, we further discuss technological limitations, knowledge gaps in the research, safety concerns and regulatory requirements that need to be considered and addressed before RNA sprays can become a reliable and realistic agricultural approach.
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spelling pubmed-85540222021-10-30 Lab-to-Field Transition of RNA Spray Applications – How Far Are We? Rank, Aline Pereira Koch, Aline Front Plant Sci Plant Science The drastic loss of biodiversity has alarmed the public and raised sociopolitical demand for chemical pesticide-free plant production, which is now treated by governments worldwide as a top priority. Given this global challenge, RNAi-based technologies are rapidly evolving as a promising substitute to conventional chemical pesticides. Primarily, genetically modified (GM) crops expressing double-stranded (ds)RNA-mediating gene silencing of foreign transcripts have been developed. However, since the cultivation of GM RNAi crops is viewed negatively in numerous countries, GM-free exogenous RNA spray applications attract tremendous scientific and political interest. The sudden rise in demand for pesticide alternatives has boosted research on sprayable RNA biopesticides, generating significant technological developments and advancing the potential for field applications in the near future. Here we review the latest advances that could pave the way for a quick lab-to-field transition for RNA sprays, which, as safe, selective, broadly applicable, and cost-effective biopesticides, represent an innovation in sustainable crop production. Given these latest advances, we further discuss technological limitations, knowledge gaps in the research, safety concerns and regulatory requirements that need to be considered and addressed before RNA sprays can become a reliable and realistic agricultural approach. Frontiers Media S.A. 2021-10-15 /pmc/articles/PMC8554022/ /pubmed/34721485 http://dx.doi.org/10.3389/fpls.2021.755203 Text en Copyright © 2021 Rank and Koch. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Rank, Aline Pereira
Koch, Aline
Lab-to-Field Transition of RNA Spray Applications – How Far Are We?
title Lab-to-Field Transition of RNA Spray Applications – How Far Are We?
title_full Lab-to-Field Transition of RNA Spray Applications – How Far Are We?
title_fullStr Lab-to-Field Transition of RNA Spray Applications – How Far Are We?
title_full_unstemmed Lab-to-Field Transition of RNA Spray Applications – How Far Are We?
title_short Lab-to-Field Transition of RNA Spray Applications – How Far Are We?
title_sort lab-to-field transition of rna spray applications – how far are we?
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554022/
https://www.ncbi.nlm.nih.gov/pubmed/34721485
http://dx.doi.org/10.3389/fpls.2021.755203
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