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On the deformation and frequency analyses of SARS-CoV-2 at nanoscale

The SARS-CoV-2 virus, which has emerged as a Covid-19 pandemic, has had the most significant impact on people's health, economy, and lifestyle around the world today. In the present study, the SARS-CoV-2 virus is mechanically simulated to obtain its deformation and natural frequencies. The viru...

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Autores principales: Dastjerdi, Shahriar, Malikan, Mohammad, Akgöz, Bekir, Civalek, Ömer, Wiczenbach, Tomasz, Eremeyev, Victor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554078/
https://www.ncbi.nlm.nih.gov/pubmed/34728858
http://dx.doi.org/10.1016/j.ijengsci.2021.103604
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author Dastjerdi, Shahriar
Malikan, Mohammad
Akgöz, Bekir
Civalek, Ömer
Wiczenbach, Tomasz
Eremeyev, Victor A.
author_facet Dastjerdi, Shahriar
Malikan, Mohammad
Akgöz, Bekir
Civalek, Ömer
Wiczenbach, Tomasz
Eremeyev, Victor A.
author_sort Dastjerdi, Shahriar
collection PubMed
description The SARS-CoV-2 virus, which has emerged as a Covid-19 pandemic, has had the most significant impact on people's health, economy, and lifestyle around the world today. In the present study, the SARS-CoV-2 virus is mechanically simulated to obtain its deformation and natural frequencies. The virus under analysis is modeled on a viscoelastic spherical structure. The theory of shell structures in mechanics is used to derive the governing equations. Whereas the virus has nanometric size, using classical theories may give incorrect results. Consequently, the nonlocal elasticity theory is used to consider the effect of interatomic forces on the results. From the mechanical point of view, if a structure vibrates with a natural frequency specific to it, the resonance phenomenon will occur in that structure, leading to its destruction. Therefore, it is possible that the protein chains of SARS-CoV-2 would be destroyed by vibrating it at natural frequencies. Since the mechanical properties of SARS-CoV-2 are not clearly known due to the new emergence of this virus, deformation and natural frequencies are obtained in a specific interval. Researchers could also use this investigation as a pioneering study to find a non-vaccine treatment solution for the SARS-CoV-2 virus and various viruses, including HIV.
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spelling pubmed-85540782021-10-29 On the deformation and frequency analyses of SARS-CoV-2 at nanoscale Dastjerdi, Shahriar Malikan, Mohammad Akgöz, Bekir Civalek, Ömer Wiczenbach, Tomasz Eremeyev, Victor A. Int J Eng Sci Article The SARS-CoV-2 virus, which has emerged as a Covid-19 pandemic, has had the most significant impact on people's health, economy, and lifestyle around the world today. In the present study, the SARS-CoV-2 virus is mechanically simulated to obtain its deformation and natural frequencies. The virus under analysis is modeled on a viscoelastic spherical structure. The theory of shell structures in mechanics is used to derive the governing equations. Whereas the virus has nanometric size, using classical theories may give incorrect results. Consequently, the nonlocal elasticity theory is used to consider the effect of interatomic forces on the results. From the mechanical point of view, if a structure vibrates with a natural frequency specific to it, the resonance phenomenon will occur in that structure, leading to its destruction. Therefore, it is possible that the protein chains of SARS-CoV-2 would be destroyed by vibrating it at natural frequencies. Since the mechanical properties of SARS-CoV-2 are not clearly known due to the new emergence of this virus, deformation and natural frequencies are obtained in a specific interval. Researchers could also use this investigation as a pioneering study to find a non-vaccine treatment solution for the SARS-CoV-2 virus and various viruses, including HIV. Elsevier Ltd. 2022-01-01 2021-10-29 /pmc/articles/PMC8554078/ /pubmed/34728858 http://dx.doi.org/10.1016/j.ijengsci.2021.103604 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Dastjerdi, Shahriar
Malikan, Mohammad
Akgöz, Bekir
Civalek, Ömer
Wiczenbach, Tomasz
Eremeyev, Victor A.
On the deformation and frequency analyses of SARS-CoV-2 at nanoscale
title On the deformation and frequency analyses of SARS-CoV-2 at nanoscale
title_full On the deformation and frequency analyses of SARS-CoV-2 at nanoscale
title_fullStr On the deformation and frequency analyses of SARS-CoV-2 at nanoscale
title_full_unstemmed On the deformation and frequency analyses of SARS-CoV-2 at nanoscale
title_short On the deformation and frequency analyses of SARS-CoV-2 at nanoscale
title_sort on the deformation and frequency analyses of sars-cov-2 at nanoscale
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554078/
https://www.ncbi.nlm.nih.gov/pubmed/34728858
http://dx.doi.org/10.1016/j.ijengsci.2021.103604
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