Transient sensory symptoms among first-dose recipients of the BNT162b2 mRNA COVID-19 vaccine: A case-control study

mRNA-based COVID-19 vaccines are effective; however, persistent vaccine hesitancy is partly due to a misperception of their potential adverse events. Non-specific sensory symptoms (NSSS) following immunization are thought to be mediated by stress-related responses. In this case-control study, we eva...

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Detalles Bibliográficos
Autores principales: García-Grimshaw, Miguel, Ceballos-Liceaga, Santa Elizabeth, Michel-Chávez, Anaclara, García-Alanis, Mario, Cadena-Fernández, Arturo, Galnares-Olalde, Javier Andrés, Carbajal-Sandoval, Guillermo, Carrillo-García, Daniel Amado, Hernández-Valdivia, Noé, Hernández-Vanegas, Laura E., Saniger-Alba, María del Mar, Gutierrez-Romero, Alonso, Díaz-Ortega, José Luis, Reyes-Terán, Gustavo, López-Gatell, Hugo, Flores-Silva, Fernando Daniel, Cantú-Brito, Carlos, Chiquete, Erwin, Arauz, Antonio, Valdés-Ferrer, Sergio Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554108/
https://www.ncbi.nlm.nih.gov/pubmed/34742595
http://dx.doi.org/10.1016/j.vaccine.2021.10.058
Descripción
Sumario:mRNA-based COVID-19 vaccines are effective; however, persistent vaccine hesitancy is partly due to a misperception of their potential adverse events. Non-specific sensory symptoms (NSSS) following immunization are thought to be mediated by stress-related responses. In this case-control study, we evaluated NSSS from a cohort of 7,812,845 BNT162b2 first-dose recipients, of whom 10,929 reported an adverse event following immunization (AEFI). We found an overall frequency of 3.4% (377 cases) or 4.8 cases per 100,000 doses administered. Anatomically, the arms (61%) and face/neck region (36.2%) were the most commonly affected sites. The control group had significantly higher rates of reactogenicity-associated symptoms, suggesting that NSSS are reactogenicity-independent; in multivariable analysis, healthcare workers reported sensory symptoms less frequently (aOR 0.54; 95% CI 0.40–0.72; p < 0.001). This is the first study describing the topography and associated factors for developing NSSS among BNT162b2 recipients. The benign nature of these symptoms may help dissipate hesitation towards this vaccine.

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