An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging

Huntington’s disease is a dominantly inherited neurodegenerative disorder caused by the expansion of a CAG repeat, encoding for the amino acid glutamine (Q), present in the first exon of the protein huntingtin. Over the threshold of Q39 HTT exon 1 (HTTEx1) tends to misfold and aggregate into large i...

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Detalles Bibliográficos
Autores principales: Pigazzini, Maria Lucia, Lawrenz, Mandy, Margineanu, Anca, Kaminski Schierle, Gabriele S., Kirstein, Janine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554126/
https://www.ncbi.nlm.nih.gov/pubmed/34720872
http://dx.doi.org/10.3389/fnmol.2021.721749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554126/
https://www.ncbi.nlm.nih.gov/pubmed/34720872
http://dx.doi.org/10.3389/fnmol.2021.721749

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