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Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging

Hair follicle stem cells are extensively reprogrammed by the aging process, manifesting as diminished self-renewal and delayed responsiveness to activating cues, orchestrated by both intrinsic microenvironmental and extrinsic macroenvironmental regulators. Dermal white adipose tissue (dWAT) is one o...

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Autores principales: Chen, Jian, Fan, Zhe-Xiang, Zhu, De-Cong, Guo, Yi-Long, Ye, Ke, Dai, Damao, Guo, Zhi, Hu, Zhi-Qi, Miao, Yong, Qu, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554130/
https://www.ncbi.nlm.nih.gov/pubmed/34722509
http://dx.doi.org/10.3389/fcell.2021.728188
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author Chen, Jian
Fan, Zhe-Xiang
Zhu, De-Cong
Guo, Yi-Long
Ye, Ke
Dai, Damao
Guo, Zhi
Hu, Zhi-Qi
Miao, Yong
Qu, Qian
author_facet Chen, Jian
Fan, Zhe-Xiang
Zhu, De-Cong
Guo, Yi-Long
Ye, Ke
Dai, Damao
Guo, Zhi
Hu, Zhi-Qi
Miao, Yong
Qu, Qian
author_sort Chen, Jian
collection PubMed
description Hair follicle stem cells are extensively reprogrammed by the aging process, manifesting as diminished self-renewal and delayed responsiveness to activating cues, orchestrated by both intrinsic microenvironmental and extrinsic macroenvironmental regulators. Dermal white adipose tissue (dWAT) is one of the peripheral tissues directly adjacent to hair follicles (HFs) and acts as a critical macroenvironmental niche of HF. dWAT directly contributes to HF aging by paracrine signal secretion. However, the altered interrelationship between dWAT and HF with aging has not been thoroughly understood. Here, through microdissection, we separated dWAT from the skin of aged mice (18 months) and young mice (2 months) in telogen and depilation-induced anagen for transcriptome comparing. Notably, compared with young dWAT, aberrant inflammatory regulators were recapitulated in aging dWAT in telogen, including substantial overexpressed inflammatory cytokines, matrix metalloproteinases, and prostaglandin members. Nonetheless, with anagen initiation, inflammation programs were mostly abolished in aging dWAT, and instead of which, impaired collagen biosynthesis, angiogenesis, and melanin synthesis were identified. Furthermore, we confirmed the inhibitory effect on hair growth of CXCL1, one of the most significantly upregulated inflammation cytokines in aging dWAT. Besides this, we also identified the under-expressed genes related to Wnt signaling fibroblast growth factor family members and increased BMP signaling in aging dWAT, further unraveling the emerging role of dWAT in aging HFs malfunction. Finally, we proved that relieving inflammation of aging dWAT by injecting high-level veratric acid stimulated HF regenerative behavior in aged mice. Concomitantly, significantly decreased TNF-a, CCL2, IL-5, CSF2, and increased IL10 in dWAT was identified. Overall, the results elaborated on the complex physiological cycling changes of dWAT during aging, providing a basis for the potential regulatory effect of dWAT on aging HFs.
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spelling pubmed-85541302021-10-30 Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Chen, Jian Fan, Zhe-Xiang Zhu, De-Cong Guo, Yi-Long Ye, Ke Dai, Damao Guo, Zhi Hu, Zhi-Qi Miao, Yong Qu, Qian Front Cell Dev Biol Cell and Developmental Biology Hair follicle stem cells are extensively reprogrammed by the aging process, manifesting as diminished self-renewal and delayed responsiveness to activating cues, orchestrated by both intrinsic microenvironmental and extrinsic macroenvironmental regulators. Dermal white adipose tissue (dWAT) is one of the peripheral tissues directly adjacent to hair follicles (HFs) and acts as a critical macroenvironmental niche of HF. dWAT directly contributes to HF aging by paracrine signal secretion. However, the altered interrelationship between dWAT and HF with aging has not been thoroughly understood. Here, through microdissection, we separated dWAT from the skin of aged mice (18 months) and young mice (2 months) in telogen and depilation-induced anagen for transcriptome comparing. Notably, compared with young dWAT, aberrant inflammatory regulators were recapitulated in aging dWAT in telogen, including substantial overexpressed inflammatory cytokines, matrix metalloproteinases, and prostaglandin members. Nonetheless, with anagen initiation, inflammation programs were mostly abolished in aging dWAT, and instead of which, impaired collagen biosynthesis, angiogenesis, and melanin synthesis were identified. Furthermore, we confirmed the inhibitory effect on hair growth of CXCL1, one of the most significantly upregulated inflammation cytokines in aging dWAT. Besides this, we also identified the under-expressed genes related to Wnt signaling fibroblast growth factor family members and increased BMP signaling in aging dWAT, further unraveling the emerging role of dWAT in aging HFs malfunction. Finally, we proved that relieving inflammation of aging dWAT by injecting high-level veratric acid stimulated HF regenerative behavior in aged mice. Concomitantly, significantly decreased TNF-a, CCL2, IL-5, CSF2, and increased IL10 in dWAT was identified. Overall, the results elaborated on the complex physiological cycling changes of dWAT during aging, providing a basis for the potential regulatory effect of dWAT on aging HFs. Frontiers Media S.A. 2021-10-15 /pmc/articles/PMC8554130/ /pubmed/34722509 http://dx.doi.org/10.3389/fcell.2021.728188 Text en Copyright © 2021 Chen, Fan, Zhu, Guo, Ye, Dai, Guo, Hu, Miao and Qu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Jian
Fan, Zhe-Xiang
Zhu, De-Cong
Guo, Yi-Long
Ye, Ke
Dai, Damao
Guo, Zhi
Hu, Zhi-Qi
Miao, Yong
Qu, Qian
Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
title Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
title_full Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
title_fullStr Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
title_full_unstemmed Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
title_short Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
title_sort emerging role of dermal white adipose tissue in modulating hair follicle development during aging
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554130/
https://www.ncbi.nlm.nih.gov/pubmed/34722509
http://dx.doi.org/10.3389/fcell.2021.728188
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