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MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13

Prostate cancer (PCa) has become the most frequently occurring cancer among western men according to the latest report, and patients’ prognosis is often poor in the event of tumor progression, therefore, many researches are devoted to exploring the molecular mechanism of PCa metastasis. MicroRNAs (m...

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Autores principales: Liu, Yangzhou, Zhao, Shankun, Wang, Jiamin, Zhu, Zhiguo, Luo, Lianmin, Xiang, Qian, Zhou, Mingda, Ma, Yuxiang, Wang, Zuomin, Zhao, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554144/
https://www.ncbi.nlm.nih.gov/pubmed/34722307
http://dx.doi.org/10.3389/fonc.2021.754353
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author Liu, Yangzhou
Zhao, Shankun
Wang, Jiamin
Zhu, Zhiguo
Luo, Lianmin
Xiang, Qian
Zhou, Mingda
Ma, Yuxiang
Wang, Zuomin
Zhao, Zhigang
author_facet Liu, Yangzhou
Zhao, Shankun
Wang, Jiamin
Zhu, Zhiguo
Luo, Lianmin
Xiang, Qian
Zhou, Mingda
Ma, Yuxiang
Wang, Zuomin
Zhao, Zhigang
author_sort Liu, Yangzhou
collection PubMed
description Prostate cancer (PCa) has become the most frequently occurring cancer among western men according to the latest report, and patients’ prognosis is often poor in the event of tumor progression, therefore, many researches are devoted to exploring the molecular mechanism of PCa metastasis. MicroRNAs (miRNA) have proved to play an important role in this process. In present study, by combining clinical samples with public databases, we found that miR-629-5p increased to varying degrees in primary localized PCa tissues and metastatic PCa tissues compared with adjacent normal tissues, and bioinformatics analysis suggested that high level of miR-629-5p was related to poor prognosis. Functionally, miR-629-5p drove PCa cell proliferation, migration and invasion in vitro, and promoted growth of PCa cells in vivo. Moreover, A-kinase Anchor Protein 13 (AKAP13) was screened as a direct target of miR-629-5p, that expression was negatively correlated with the malignant phenotype of tumor cells. In the end, through verification in clinical specimens, we found that AKAP13 could be independently used as a clinical prognostic indicator. Overall, the present study indicates that miR-629-5p plays an oncogenic role in PCa by targeting AKAP13, which provides a new idea for clinical diagnosis and treatment of complex refractory PCa.
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spelling pubmed-85541442021-10-30 MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13 Liu, Yangzhou Zhao, Shankun Wang, Jiamin Zhu, Zhiguo Luo, Lianmin Xiang, Qian Zhou, Mingda Ma, Yuxiang Wang, Zuomin Zhao, Zhigang Front Oncol Oncology Prostate cancer (PCa) has become the most frequently occurring cancer among western men according to the latest report, and patients’ prognosis is often poor in the event of tumor progression, therefore, many researches are devoted to exploring the molecular mechanism of PCa metastasis. MicroRNAs (miRNA) have proved to play an important role in this process. In present study, by combining clinical samples with public databases, we found that miR-629-5p increased to varying degrees in primary localized PCa tissues and metastatic PCa tissues compared with adjacent normal tissues, and bioinformatics analysis suggested that high level of miR-629-5p was related to poor prognosis. Functionally, miR-629-5p drove PCa cell proliferation, migration and invasion in vitro, and promoted growth of PCa cells in vivo. Moreover, A-kinase Anchor Protein 13 (AKAP13) was screened as a direct target of miR-629-5p, that expression was negatively correlated with the malignant phenotype of tumor cells. In the end, through verification in clinical specimens, we found that AKAP13 could be independently used as a clinical prognostic indicator. Overall, the present study indicates that miR-629-5p plays an oncogenic role in PCa by targeting AKAP13, which provides a new idea for clinical diagnosis and treatment of complex refractory PCa. Frontiers Media S.A. 2021-10-15 /pmc/articles/PMC8554144/ /pubmed/34722307 http://dx.doi.org/10.3389/fonc.2021.754353 Text en Copyright © 2021 Liu, Zhao, Wang, Zhu, Luo, Xiang, Zhou, Ma, Wang and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Yangzhou
Zhao, Shankun
Wang, Jiamin
Zhu, Zhiguo
Luo, Lianmin
Xiang, Qian
Zhou, Mingda
Ma, Yuxiang
Wang, Zuomin
Zhao, Zhigang
MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13
title MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13
title_full MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13
title_fullStr MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13
title_full_unstemmed MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13
title_short MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13
title_sort mir-629-5p promotes prostate cancer development and metastasis by targeting akap13
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554144/
https://www.ncbi.nlm.nih.gov/pubmed/34722307
http://dx.doi.org/10.3389/fonc.2021.754353
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