Anterior chamber infiltration of CAR T-cells

A unique image of anterior chamber infiltration in a 2-year-infant with leukemia, treated with CD19 CAR T cells. Despite significant lymphopenia and resemblance of fungal infection initially, biopsy and cytologic analysis from anterior chamber fluid confirmed that this was CAR T-cell infiltration, l...

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Detalles Bibliográficos
Autores principales: Jacoby, Elad, Zloto, Ofira, Vishnevskia Dai, Vicktoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554163/
https://www.ncbi.nlm.nih.gov/pubmed/34746512
http://dx.doi.org/10.1016/j.ajoc.2021.101223
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author Jacoby, Elad
Zloto, Ofira
Vishnevskia Dai, Vicktoria
author_facet Jacoby, Elad
Zloto, Ofira
Vishnevskia Dai, Vicktoria
author_sort Jacoby, Elad
collection PubMed
description A unique image of anterior chamber infiltration in a 2-year-infant with leukemia, treated with CD19 CAR T cells. Despite significant lymphopenia and resemblance of fungal infection initially, biopsy and cytologic analysis from anterior chamber fluid confirmed that this was CAR T-cell infiltration, likely targeting microscopic leukemia, unknown to us treating physicians. This is a unique case in 2 aspects: first, to state the high quality of CAR T-cell trafficking; and second – given the wide use of these cells currently, this image may help educate clinicians regarding this potential diagnosis.
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spelling pubmed-85541632021-11-05 Anterior chamber infiltration of CAR T-cells Jacoby, Elad Zloto, Ofira Vishnevskia Dai, Vicktoria Am J Ophthalmol Case Rep Images A unique image of anterior chamber infiltration in a 2-year-infant with leukemia, treated with CD19 CAR T cells. Despite significant lymphopenia and resemblance of fungal infection initially, biopsy and cytologic analysis from anterior chamber fluid confirmed that this was CAR T-cell infiltration, likely targeting microscopic leukemia, unknown to us treating physicians. This is a unique case in 2 aspects: first, to state the high quality of CAR T-cell trafficking; and second – given the wide use of these cells currently, this image may help educate clinicians regarding this potential diagnosis. Elsevier 2021-10-22 /pmc/articles/PMC8554163/ /pubmed/34746512 http://dx.doi.org/10.1016/j.ajoc.2021.101223 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Images
Jacoby, Elad
Zloto, Ofira
Vishnevskia Dai, Vicktoria
Anterior chamber infiltration of CAR T-cells
title Anterior chamber infiltration of CAR T-cells
title_full Anterior chamber infiltration of CAR T-cells
title_fullStr Anterior chamber infiltration of CAR T-cells
title_full_unstemmed Anterior chamber infiltration of CAR T-cells
title_short Anterior chamber infiltration of CAR T-cells
title_sort anterior chamber infiltration of car t-cells
topic Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554163/
https://www.ncbi.nlm.nih.gov/pubmed/34746512
http://dx.doi.org/10.1016/j.ajoc.2021.101223
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AT vishnevskiadaivicktoria anteriorchamberinfiltrationofcartcells

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