Inhibition of Bromodomain and Extra Terminal (BET) Domain Activity Modulates the IL-23R/IL-17 Axis and Suppresses Acute Graft-Versus-Host Disease

Acute graft-versus-host disease (GVHD) is the leading cause of non-relapse mortality following allogeneic hematopoietic cell transplantation. The majority of patients non-responsive to front line treatment with steroids have an estimated overall 2-year survival rate of only 10%. Bromodomain and extr...

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Detalles Bibliográficos
Autores principales: Snyder, Katiri J., Choe, Hannah K., Gao, Yandi, Sell, Natalie E., Braunreiter, Kara M., Zitzer, Nina C., Neidemire-Colley, Lotus, Kalyan, Sonu, Dorrance, Adrienne M., Keller, Andrea, Mihaylova, Maria M., Singh, Satishkumar, Sehgal, Lalit, Bollag, Gideon, Ma, Yan, Powell, Ben, Devine, Steven M., Ranganathan, Parvathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554203/
https://www.ncbi.nlm.nih.gov/pubmed/34722316
http://dx.doi.org/10.3389/fonc.2021.760789

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