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Mini Review: Advances in 2-Haloacid Dehalogenases
The 2-haloacid dehalogenases (EC 3.8.1.X) are industrially important enzymes that catalyze the cleavage of carbon–halogen bonds in 2-haloalkanoic acids, releasing halogen ions and producing corresponding 2-hydroxyl acids. These enzymes are of particular interest in environmental remediation and envi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554231/ https://www.ncbi.nlm.nih.gov/pubmed/34721367 http://dx.doi.org/10.3389/fmicb.2021.758886 |
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author | Wang, Yayue Xiang, Qiao Zhou, Qingfeng Xu, Jingliang Pei, Dongli |
author_facet | Wang, Yayue Xiang, Qiao Zhou, Qingfeng Xu, Jingliang Pei, Dongli |
author_sort | Wang, Yayue |
collection | PubMed |
description | The 2-haloacid dehalogenases (EC 3.8.1.X) are industrially important enzymes that catalyze the cleavage of carbon–halogen bonds in 2-haloalkanoic acids, releasing halogen ions and producing corresponding 2-hydroxyl acids. These enzymes are of particular interest in environmental remediation and environmentally friendly synthesis of optically pure chiral compounds due to their ability to degrade a wide range of halogenated compounds with astonishing efficiency for enantiomer resolution. The 2-haloacid dehalogenases have been extensively studied with regard to their biochemical characterization, protein crystal structures, and catalytic mechanisms. This paper comprehensively reviews the source of isolation, classification, protein structures, reaction mechanisms, biochemical properties, and application of 2-haloacid dehalogenases; current trends and avenues for further development have also been included. |
format | Online Article Text |
id | pubmed-8554231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85542312021-10-30 Mini Review: Advances in 2-Haloacid Dehalogenases Wang, Yayue Xiang, Qiao Zhou, Qingfeng Xu, Jingliang Pei, Dongli Front Microbiol Microbiology The 2-haloacid dehalogenases (EC 3.8.1.X) are industrially important enzymes that catalyze the cleavage of carbon–halogen bonds in 2-haloalkanoic acids, releasing halogen ions and producing corresponding 2-hydroxyl acids. These enzymes are of particular interest in environmental remediation and environmentally friendly synthesis of optically pure chiral compounds due to their ability to degrade a wide range of halogenated compounds with astonishing efficiency for enantiomer resolution. The 2-haloacid dehalogenases have been extensively studied with regard to their biochemical characterization, protein crystal structures, and catalytic mechanisms. This paper comprehensively reviews the source of isolation, classification, protein structures, reaction mechanisms, biochemical properties, and application of 2-haloacid dehalogenases; current trends and avenues for further development have also been included. Frontiers Media S.A. 2021-10-15 /pmc/articles/PMC8554231/ /pubmed/34721367 http://dx.doi.org/10.3389/fmicb.2021.758886 Text en Copyright © 2021 Wang, Xiang, Zhou, Xu and Pei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Wang, Yayue Xiang, Qiao Zhou, Qingfeng Xu, Jingliang Pei, Dongli Mini Review: Advances in 2-Haloacid Dehalogenases |
title | Mini Review: Advances in 2-Haloacid Dehalogenases |
title_full | Mini Review: Advances in 2-Haloacid Dehalogenases |
title_fullStr | Mini Review: Advances in 2-Haloacid Dehalogenases |
title_full_unstemmed | Mini Review: Advances in 2-Haloacid Dehalogenases |
title_short | Mini Review: Advances in 2-Haloacid Dehalogenases |
title_sort | mini review: advances in 2-haloacid dehalogenases |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554231/ https://www.ncbi.nlm.nih.gov/pubmed/34721367 http://dx.doi.org/10.3389/fmicb.2021.758886 |
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