Cargando…

Small conductance calcium activated K(+) channel inhibitor decreases stretch induced vulnerability to atrial fibrillation

BACKGROUND: Atrial dilation is an important risk factor for atrial fibrillation (AF) and animal studies have found that acute atrial dilation shortens the atrial effective refractory period (AERP) and increases the risk of AF. Stretch activated ion channels (SACs) and calcium channels play a role in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Yannan, Skarsfeldt, Mark Alexander, Diness, Jonas Goldin, Bentzen, Bo Hjorth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554272/ https://www.ncbi.nlm.nih.gov/pubmed/34746364 http://dx.doi.org/10.1016/j.ijcha.2021.100898

Ejemplares similares

Inhibition of K(Ca)2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia
por: Diness, Jonas Goldin, et al.
Publicado: (2020)

The K(Ca)2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs
por: Diness, Jonas Goldin, et al.
Publicado: (2020)

Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy
por: Diness, Jonas G., et al.
Publicado: (2015)

Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction
por: Gatta, Giulia, et al.
Publicado: (2021)

Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca(2+)-Activated K(+) Channels in Pigs
por: Diness, Jonas Goldin, et al.
Publicado: (2017)

The K(Ca)2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
por: Kirchhoff, Jeppe Egedal, et al.
Publicado: (2019)

Inhibition of K(Ca)2 and K(v)11.1 Channels in Pigs With Left Ventricular Dysfunction
por: Citerni, Carlotta, et al.
Publicado: (2020)

Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing
por: Citerni, Carlotta, et al.
Publicado: (2020)

Whole-Exome Sequencing Implicates Neuronal Calcium Channel with Familial Atrial Fibrillation
por: Vad, Oliver Bundgaard, et al.
Publicado: (2022)

Pharmacological inhibition of SK‐channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events
por: Linz, Benedikt, et al.
Publicado: (2022)

Inhibition of Small-Conductance Calcium-Activated Potassium Current (I(K,Ca)) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation
por: Fenner, Merle Friederike, et al.
Publicado: (2021)

Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation
por: Kirchhoff, Jeppe Egedal, et al.
Publicado: (2016)

Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man
por: Bentzen, Bo Hjorth, et al.
Publicado: (2020)

First Clinical Study with AP30663 ‐ a K(Ca)2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation
por: Gal, Pim, et al.
Publicado: (2020)

Blocking Intermediate-Conductance Calcium-Activated Potassium Channels in the Macrophages Around Ganglionated Plexi Suppresses Atrial Fibrillation Vulnerability in Canines With Rapid Atrial Pacing
por: Ma, Yazhe, et al.
Publicado: (2022)

A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation
por: Hansen, Thea Hyttel, et al.
Publicado: (2020)

Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation
por: Soattin, Luca, et al.
Publicado: (2020)

Left atrial effective conducting size predicts atrial fibrillation vulnerability in persistent but not paroxysmal atrial fibrillation
por: Williams, Steven E., et al.
Publicado: (2019)

Endocannabinoids enhance hK(V)7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval
por: Hiniesto-Iñigo, Irene, et al.
Publicado: (2023)

Investigating gene-microRNA networks in atrial fibrillation patients with mitral valve regurgitation
por: Larupa Santos, Joana, et al.
Publicado: (2020)

Carbon monoxide releasing molecule-2 suppresses stretch-activated atrial natriuretic peptide secretion by activating large-conductance calcium-activated potassium channels
por: Li, Weijian, et al.
Publicado: (2022)

Stretching the limits of antiarrhythmic drug therapy: The promise of small-conductance calcium-activated potassium channel blockers()
por: Heijman, Jordi, et al.
Publicado: (2021)

The role of gap junctions in stretch-induced atrial fibrillation
por: Ueda, Norihiro, et al.
Publicado: (2014)

Inhibitory Effects of Dronedarone on Small Conductance Calcium Activated Potassium Channels in Patients with Chronic Atrial Fibrillation: Comparison to Amiodarone
por: Yu, Yiyan, et al.
Publicado: (2020)

Doxycycline Improves Fibrosis-Induced Abnormalities in Atrial Conduction and Vulnerability to Atrial Fibrillation in Chronic Intermittent Hypoxia Rats
por: Ma, Zuowang, et al.
Publicado: (2020)

Acute atrial wall stretch and the efficacy of flecainide-induced conversion of atrial fibrillation
por: van Hemel, N.M., et al.
Publicado: (2015)

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation
por: Olesen, Morten S, et al.
Publicado: (2012)

SK4 calcium-activated potassium channels activated by sympathetic nerves enhances atrial fibrillation vulnerability in a canine model of acute stroke
por: Yang, Mei, et al.
Publicado: (2020)

Gating of Recombinant Small-Conductance Ca-activated K(+) Channels by Calcium
por: Hirschberg, Birgit, et al.
Publicado: (1998)

Modulation of TRESK Background K(+) Channel by Membrane Stretch
por: Callejo, Gerard, et al.
Publicado: (2013)

Angiotensin Receptor Blocker and Calcium Channel Blocker Preventing Atrial Fibrillation Recurrence in Patients with Hypertension and Atrial Fibrillation: A Meta-analysis
por: Ma, Haotian, et al.
Publicado: (2021)

Pharmacological inhibition of I(K) (1) by PA‐6 in isolated rat hearts affects ventricular repolarization and refractoriness
por: Skarsfeldt, Mark A., et al.
Publicado: (2016)

Magnetocardiography on an isolated animal heart with a room-temperature optically pumped magnetometer
por: Jensen, Kasper, et al.
Publicado: (2018)

Reduction of Conduction Velocity in Patients with Atrial Fibrillation
por: Heida, Annejet, et al.
Publicado: (2021)

The Large Conductance, Calcium-activated K(+) (BK) Channel is regulated by Cysteine String Protein
por: Kyle, Barry D., et al.
Publicado: (2013)

Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels
por: Gopal, Sandeep, et al.
Publicado: (2015)

2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels
por: Simó-Vicens, Rafel, et al.
Publicado: (2018)

Trigger-Specific Remodeling of K(Ca)2 Potassium Channels in Models of Atrial Fibrillation
por: Rahm, Ann-Kathrin, et al.
Publicado: (2021)

Increased Density of Endogenous Adenosine A(2A) Receptors in Atrial Fibrillation: From Cellular and Porcine Models to Human Patients
por: Godoy-Marín, Héctor, et al.
Publicado: (2023)

Small Conductance Ca(2 +)-Activated K(+) (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue
por: Darkow, Elisa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ton9e50l71tmgc4dtsforhvlp1