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Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats

OBJECTIVE: Medicinal plants provide better and cheaper alternative therapy for management of several diseases compared to orthodox medicines. This study evaluated the effects of feed formulated with Ficus ottoniifolia (Miq.) Miq. (FFFO) leaves in the management of alloxan-induced diabetes mellitus (...

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Autores principales: Aloke, Chinyere, Nwachukwu, Ngwu, Obasi, Nwogo Ajuka, Emelike, Chinedum Uche, Amu, Pascal Anyaegbunam, Ogbu, Patience Nkemjika, Orinya, Onyebuchi Federick, Ogbonnia, Egwu Chinedu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554283/
https://www.ncbi.nlm.nih.gov/pubmed/34745915
http://dx.doi.org/10.22038/AJP.2020.16958
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author Aloke, Chinyere
Nwachukwu, Ngwu
Obasi, Nwogo Ajuka
Emelike, Chinedum Uche
Amu, Pascal Anyaegbunam
Ogbu, Patience Nkemjika
Orinya, Onyebuchi Federick
Ogbonnia, Egwu Chinedu
author_facet Aloke, Chinyere
Nwachukwu, Ngwu
Obasi, Nwogo Ajuka
Emelike, Chinedum Uche
Amu, Pascal Anyaegbunam
Ogbu, Patience Nkemjika
Orinya, Onyebuchi Federick
Ogbonnia, Egwu Chinedu
author_sort Aloke, Chinyere
collection PubMed
description OBJECTIVE: Medicinal plants provide better and cheaper alternative therapy for management of several diseases compared to orthodox medicines. This study evaluated the effects of feed formulated with Ficus ottoniifolia (Miq.) Miq. (FFFO) leaves in the management of alloxan-induced diabetes mellitus (DM) in rats. MATERIALS AND METHODS: DM was induced in overnight-fasted rats by administration of alloxan monohydrate intraperitoneally. DM rats in Groups 1−3 were fed with graded FFFO while group 4 (diabetic control) and group 5 (normal control) were fed with commercial feeds (Vital-Feeds), daily for 21 days. Changes in body weight and some biochemical parameters were thereafter determined. RESULTS: Results showed significant decreases (p<0.05) in serum high-density lipoprotein (HDL) but significant increases (p<0.05) in blood glucose, serum low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and alanine aminotransferase (ALT) activities in DM-induced rats compared to the normal control group. Feeding with FFFO significantly increased (p<0.05) the body weight and HDL, decreased the blood glucose, serum LDL, TG and TC and attenuated ALT activities in FFFO-fed DM rats compared to the diabetic control group. CONCLUSION: This study revealed that FFFO-diet may mitigate hyperglycemia, dyslipidemia and liver-damage associated with DM.
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spelling pubmed-85542832021-11-05 Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats Aloke, Chinyere Nwachukwu, Ngwu Obasi, Nwogo Ajuka Emelike, Chinedum Uche Amu, Pascal Anyaegbunam Ogbu, Patience Nkemjika Orinya, Onyebuchi Federick Ogbonnia, Egwu Chinedu Avicenna J Phytomed Short Communication OBJECTIVE: Medicinal plants provide better and cheaper alternative therapy for management of several diseases compared to orthodox medicines. This study evaluated the effects of feed formulated with Ficus ottoniifolia (Miq.) Miq. (FFFO) leaves in the management of alloxan-induced diabetes mellitus (DM) in rats. MATERIALS AND METHODS: DM was induced in overnight-fasted rats by administration of alloxan monohydrate intraperitoneally. DM rats in Groups 1−3 were fed with graded FFFO while group 4 (diabetic control) and group 5 (normal control) were fed with commercial feeds (Vital-Feeds), daily for 21 days. Changes in body weight and some biochemical parameters were thereafter determined. RESULTS: Results showed significant decreases (p<0.05) in serum high-density lipoprotein (HDL) but significant increases (p<0.05) in blood glucose, serum low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and alanine aminotransferase (ALT) activities in DM-induced rats compared to the normal control group. Feeding with FFFO significantly increased (p<0.05) the body weight and HDL, decreased the blood glucose, serum LDL, TG and TC and attenuated ALT activities in FFFO-fed DM rats compared to the diabetic control group. CONCLUSION: This study revealed that FFFO-diet may mitigate hyperglycemia, dyslipidemia and liver-damage associated with DM. Mashhad University of Medical Sciences 2021 /pmc/articles/PMC8554283/ /pubmed/34745915 http://dx.doi.org/10.22038/AJP.2020.16958 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Aloke, Chinyere
Nwachukwu, Ngwu
Obasi, Nwogo Ajuka
Emelike, Chinedum Uche
Amu, Pascal Anyaegbunam
Ogbu, Patience Nkemjika
Orinya, Onyebuchi Federick
Ogbonnia, Egwu Chinedu
Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats
title Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats
title_full Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats
title_fullStr Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats
title_full_unstemmed Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats
title_short Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats
title_sort antihyperglycemic, antihyperlipidemic and hepatoprotective effects of ficus ottoniifolia (miq.) miq. supplementation in alloxan-induced diabetic rats
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554283/
https://www.ncbi.nlm.nih.gov/pubmed/34745915
http://dx.doi.org/10.22038/AJP.2020.16958
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