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Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography
OBJECTIVE: Coronary artery disease (CAD) is among the most prevalent diseases in the world, and its severity is usually assessed through coronary angiography (CA). Anxiety is the most prevalent problem before angiography. The aim of this study was to evaluate Crocus sativus (saffron) and Lippia citr...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Mashhad University of Medical Sciences
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554287/ https://www.ncbi.nlm.nih.gov/pubmed/34745923 http://dx.doi.org/10.22038/AJP.2021.18077 |
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author | Soheilipur, Kobra Khazdair, Mohammad Reza Moezi, Seyyed Ali Mahmoudirad, Gholamhossein |
author_facet | Soheilipur, Kobra Khazdair, Mohammad Reza Moezi, Seyyed Ali Mahmoudirad, Gholamhossein |
author_sort | Soheilipur, Kobra |
collection | PubMed |
description | OBJECTIVE: Coronary artery disease (CAD) is among the most prevalent diseases in the world, and its severity is usually assessed through coronary angiography (CA). Anxiety is the most prevalent problem before angiography. The aim of this study was to evaluate Crocus sativus (saffron) and Lippia citriodora Kunth (lippia) extracts and saffron-lippia extract combination on anxiety among the candidates for CA. MATERIALS AND METHODS: This double-blind randomized placebo-controlled trial in four month was conducted on 120 angiography candidates in Valiasr hospital, Birjand, Iran. The random allocation was doing through block randomization to saffron, lippia, saffron-lippia, and placebo groups; four hours before angiography, participants in these groups respectively received a single dose of saffron extract capsule (40 mg), lippia extract capsule (40 mg), saffron-lippia extract capsule (20 mg saffron and 20 mg lippia), and lactulose capsule (40 mg). Participants’ anxiety was assessed before, thirty minutes after, and three hours after the intervention via Spielberger State-Trait Anxiety Inventory. RESULTS: The mean scores of state, trait, and total anxiety in the saffron group reduced significantly (p<0.05), while the mean scores in the other groups did not change significantly, except for the mean score of trait anxiety in the saffron-lippia group which decreased significantly (p=0.05). Therefore, after the intervention, the mean scores of state, trait, and total anxiety in the saffron group were significantly lower than the other groups (all, p<0.05). CONCLUSION: This study suggests that the oral use of a single-dose of 40 mg saffron extract is effective in alleviating anxiety among the candidates for CA. |
format | Online Article Text |
id | pubmed-8554287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-85542872021-11-05 Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography Soheilipur, Kobra Khazdair, Mohammad Reza Moezi, Seyyed Ali Mahmoudirad, Gholamhossein Avicenna J Phytomed Original Research Article OBJECTIVE: Coronary artery disease (CAD) is among the most prevalent diseases in the world, and its severity is usually assessed through coronary angiography (CA). Anxiety is the most prevalent problem before angiography. The aim of this study was to evaluate Crocus sativus (saffron) and Lippia citriodora Kunth (lippia) extracts and saffron-lippia extract combination on anxiety among the candidates for CA. MATERIALS AND METHODS: This double-blind randomized placebo-controlled trial in four month was conducted on 120 angiography candidates in Valiasr hospital, Birjand, Iran. The random allocation was doing through block randomization to saffron, lippia, saffron-lippia, and placebo groups; four hours before angiography, participants in these groups respectively received a single dose of saffron extract capsule (40 mg), lippia extract capsule (40 mg), saffron-lippia extract capsule (20 mg saffron and 20 mg lippia), and lactulose capsule (40 mg). Participants’ anxiety was assessed before, thirty minutes after, and three hours after the intervention via Spielberger State-Trait Anxiety Inventory. RESULTS: The mean scores of state, trait, and total anxiety in the saffron group reduced significantly (p<0.05), while the mean scores in the other groups did not change significantly, except for the mean score of trait anxiety in the saffron-lippia group which decreased significantly (p=0.05). Therefore, after the intervention, the mean scores of state, trait, and total anxiety in the saffron group were significantly lower than the other groups (all, p<0.05). CONCLUSION: This study suggests that the oral use of a single-dose of 40 mg saffron extract is effective in alleviating anxiety among the candidates for CA. Mashhad University of Medical Sciences 2021 /pmc/articles/PMC8554287/ /pubmed/34745923 http://dx.doi.org/10.22038/AJP.2021.18077 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Article Soheilipur, Kobra Khazdair, Mohammad Reza Moezi, Seyyed Ali Mahmoudirad, Gholamhossein Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography |
title | Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography |
title_full | Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography |
title_fullStr | Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography |
title_full_unstemmed | Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography |
title_short | Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography |
title_sort | comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554287/ https://www.ncbi.nlm.nih.gov/pubmed/34745923 http://dx.doi.org/10.22038/AJP.2021.18077 |
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