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Pleckstrin 2 is a potential drug target for colorectal carcinoma with activation of APC/β-catenin

The tumor suppressor gene adenomatous polyposis coli (APC) is frequently inactivated or absent in colorectal carcinoma (CRC). Loss-of-function of APC promotes the expression of β-catenin, which is critical for CRC development. Since β-catenin acts as an important transcription factor, blockage of β-...

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Detalles Bibliográficos
Autores principales:	Chai, Bao, Guo, Yarong, Zhu, Na, Jia, Junmei, Zhang, Zhuowei, Ping, Mei, Jia, Kai, Cui, Xiaolong, Suo, Yuhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554384/ https://www.ncbi.nlm.nih.gov/pubmed/34676872 http://dx.doi.org/10.3892/mmr.2021.12502

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