Cargando…

Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy

BACKGROUND: Nickel (Ni) may accumulate in the human body and has biological toxicity and carcinogenicity. Ni has an extensive impact on the health of pregnant women and fetuses during gestation. AIM: To evaluate Ni exposure in pregnant women in Kunming, Yunnan Province, China; to describe the distri...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Ai-Ling, Hu, Hong, Xu, Fan-Ping, Liu, Ling-Yan, Peng, Juan, Dong, Xu-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554420/
https://www.ncbi.nlm.nih.gov/pubmed/34754843
http://dx.doi.org/10.12998/wjcc.v9.i28.8340
_version_ 1784591795645054976
author Ding, Ai-Ling
Hu, Hong
Xu, Fan-Ping
Liu, Ling-Yan
Peng, Juan
Dong, Xu-Dong
author_facet Ding, Ai-Ling
Hu, Hong
Xu, Fan-Ping
Liu, Ling-Yan
Peng, Juan
Dong, Xu-Dong
author_sort Ding, Ai-Ling
collection PubMed
description BACKGROUND: Nickel (Ni) may accumulate in the human body and has biological toxicity and carcinogenicity. Ni has an extensive impact on the health of pregnant women and fetuses during gestation. AIM: To evaluate Ni exposure in pregnant women in Kunming, Yunnan Province, China; to describe the distribution of Ni in the maternal-fetal system and placental barrier function; and to investigate the effect of Ni exposure on fetal health in mothers with pregnancy complications. METHODS: Seventy-two pregnant women were selected using a case-control design. The women were divided into two groups: The control group (no disease; n = 29) and the disease group [gestational diabetes (GDM), hypertensive disorder complicating pregnancy (HDCP), or both; n = 43]. The pregnant women in the disease group were further divided as follows: 14 cases with GDM (GDM group), 13 cases with HDCP (HDCP group) and 16 cases with both GDM and HDCP (disease combination group). Basic information on the pregnant women was collected by questionnaire survey. Maternal blood, placenta blood and cord blood were collected immediately after delivery. The Ni content in paired samples was determined using inductively coupled plasma mass spectrometry. RESULTS: Compared to the control group, age was higher and body mass index was greater in pregnant women in the disease groups (28.14 ± 2.54 vs 28.42 ± 13.89, P < 0.05; 25.90 ± 3.86 vs 31.49 ± 5.30, P < 0.05). The birth weights of newborns in the HDCP group and the control group were significantly different (2.52 ± 0.74 vs 3.18 ± 0.41, P < 0.05). The content of Ni in umbilical cord blood in the entire disease group was higher than that in the control group (0.10 ± 0.16 vs 0.05 ± 0.07, P < 0.05). CONCLUSION: In the maternal-fetal system of women with pregnancy complications, the barrier effect of the placenta against Ni is weakened, thus affecting healthy growth of the fetus in the uterus.
format Online
Article
Text
id pubmed-8554420
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-85544202021-11-08 Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy Ding, Ai-Ling Hu, Hong Xu, Fan-Ping Liu, Ling-Yan Peng, Juan Dong, Xu-Dong World J Clin Cases Case Control Study BACKGROUND: Nickel (Ni) may accumulate in the human body and has biological toxicity and carcinogenicity. Ni has an extensive impact on the health of pregnant women and fetuses during gestation. AIM: To evaluate Ni exposure in pregnant women in Kunming, Yunnan Province, China; to describe the distribution of Ni in the maternal-fetal system and placental barrier function; and to investigate the effect of Ni exposure on fetal health in mothers with pregnancy complications. METHODS: Seventy-two pregnant women were selected using a case-control design. The women were divided into two groups: The control group (no disease; n = 29) and the disease group [gestational diabetes (GDM), hypertensive disorder complicating pregnancy (HDCP), or both; n = 43]. The pregnant women in the disease group were further divided as follows: 14 cases with GDM (GDM group), 13 cases with HDCP (HDCP group) and 16 cases with both GDM and HDCP (disease combination group). Basic information on the pregnant women was collected by questionnaire survey. Maternal blood, placenta blood and cord blood were collected immediately after delivery. The Ni content in paired samples was determined using inductively coupled plasma mass spectrometry. RESULTS: Compared to the control group, age was higher and body mass index was greater in pregnant women in the disease groups (28.14 ± 2.54 vs 28.42 ± 13.89, P < 0.05; 25.90 ± 3.86 vs 31.49 ± 5.30, P < 0.05). The birth weights of newborns in the HDCP group and the control group were significantly different (2.52 ± 0.74 vs 3.18 ± 0.41, P < 0.05). The content of Ni in umbilical cord blood in the entire disease group was higher than that in the control group (0.10 ± 0.16 vs 0.05 ± 0.07, P < 0.05). CONCLUSION: In the maternal-fetal system of women with pregnancy complications, the barrier effect of the placenta against Ni is weakened, thus affecting healthy growth of the fetus in the uterus. Baishideng Publishing Group Inc 2021-10-06 2021-10-06 /pmc/articles/PMC8554420/ /pubmed/34754843 http://dx.doi.org/10.12998/wjcc.v9.i28.8340 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Control Study
Ding, Ai-Ling
Hu, Hong
Xu, Fan-Ping
Liu, Ling-Yan
Peng, Juan
Dong, Xu-Dong
Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
title Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
title_full Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
title_fullStr Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
title_full_unstemmed Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
title_short Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
title_sort pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
topic Case Control Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554420/
https://www.ncbi.nlm.nih.gov/pubmed/34754843
http://dx.doi.org/10.12998/wjcc.v9.i28.8340
work_keys_str_mv AT dingailing pregnancycomplicationseffectonthenickelcontentinmaternalbloodplacentabloodandumbilicalcordbloodduringpregnancy
AT huhong pregnancycomplicationseffectonthenickelcontentinmaternalbloodplacentabloodandumbilicalcordbloodduringpregnancy
AT xufanping pregnancycomplicationseffectonthenickelcontentinmaternalbloodplacentabloodandumbilicalcordbloodduringpregnancy
AT liulingyan pregnancycomplicationseffectonthenickelcontentinmaternalbloodplacentabloodandumbilicalcordbloodduringpregnancy
AT pengjuan pregnancycomplicationseffectonthenickelcontentinmaternalbloodplacentabloodandumbilicalcordbloodduringpregnancy
AT dongxudong pregnancycomplicationseffectonthenickelcontentinmaternalbloodplacentabloodandumbilicalcordbloodduringpregnancy