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Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
BACKGROUND: Nickel (Ni) may accumulate in the human body and has biological toxicity and carcinogenicity. Ni has an extensive impact on the health of pregnant women and fetuses during gestation. AIM: To evaluate Ni exposure in pregnant women in Kunming, Yunnan Province, China; to describe the distri...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554420/ https://www.ncbi.nlm.nih.gov/pubmed/34754843 http://dx.doi.org/10.12998/wjcc.v9.i28.8340 |
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author | Ding, Ai-Ling Hu, Hong Xu, Fan-Ping Liu, Ling-Yan Peng, Juan Dong, Xu-Dong |
author_facet | Ding, Ai-Ling Hu, Hong Xu, Fan-Ping Liu, Ling-Yan Peng, Juan Dong, Xu-Dong |
author_sort | Ding, Ai-Ling |
collection | PubMed |
description | BACKGROUND: Nickel (Ni) may accumulate in the human body and has biological toxicity and carcinogenicity. Ni has an extensive impact on the health of pregnant women and fetuses during gestation. AIM: To evaluate Ni exposure in pregnant women in Kunming, Yunnan Province, China; to describe the distribution of Ni in the maternal-fetal system and placental barrier function; and to investigate the effect of Ni exposure on fetal health in mothers with pregnancy complications. METHODS: Seventy-two pregnant women were selected using a case-control design. The women were divided into two groups: The control group (no disease; n = 29) and the disease group [gestational diabetes (GDM), hypertensive disorder complicating pregnancy (HDCP), or both; n = 43]. The pregnant women in the disease group were further divided as follows: 14 cases with GDM (GDM group), 13 cases with HDCP (HDCP group) and 16 cases with both GDM and HDCP (disease combination group). Basic information on the pregnant women was collected by questionnaire survey. Maternal blood, placenta blood and cord blood were collected immediately after delivery. The Ni content in paired samples was determined using inductively coupled plasma mass spectrometry. RESULTS: Compared to the control group, age was higher and body mass index was greater in pregnant women in the disease groups (28.14 ± 2.54 vs 28.42 ± 13.89, P < 0.05; 25.90 ± 3.86 vs 31.49 ± 5.30, P < 0.05). The birth weights of newborns in the HDCP group and the control group were significantly different (2.52 ± 0.74 vs 3.18 ± 0.41, P < 0.05). The content of Ni in umbilical cord blood in the entire disease group was higher than that in the control group (0.10 ± 0.16 vs 0.05 ± 0.07, P < 0.05). CONCLUSION: In the maternal-fetal system of women with pregnancy complications, the barrier effect of the placenta against Ni is weakened, thus affecting healthy growth of the fetus in the uterus. |
format | Online Article Text |
id | pubmed-8554420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-85544202021-11-08 Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy Ding, Ai-Ling Hu, Hong Xu, Fan-Ping Liu, Ling-Yan Peng, Juan Dong, Xu-Dong World J Clin Cases Case Control Study BACKGROUND: Nickel (Ni) may accumulate in the human body and has biological toxicity and carcinogenicity. Ni has an extensive impact on the health of pregnant women and fetuses during gestation. AIM: To evaluate Ni exposure in pregnant women in Kunming, Yunnan Province, China; to describe the distribution of Ni in the maternal-fetal system and placental barrier function; and to investigate the effect of Ni exposure on fetal health in mothers with pregnancy complications. METHODS: Seventy-two pregnant women were selected using a case-control design. The women were divided into two groups: The control group (no disease; n = 29) and the disease group [gestational diabetes (GDM), hypertensive disorder complicating pregnancy (HDCP), or both; n = 43]. The pregnant women in the disease group were further divided as follows: 14 cases with GDM (GDM group), 13 cases with HDCP (HDCP group) and 16 cases with both GDM and HDCP (disease combination group). Basic information on the pregnant women was collected by questionnaire survey. Maternal blood, placenta blood and cord blood were collected immediately after delivery. The Ni content in paired samples was determined using inductively coupled plasma mass spectrometry. RESULTS: Compared to the control group, age was higher and body mass index was greater in pregnant women in the disease groups (28.14 ± 2.54 vs 28.42 ± 13.89, P < 0.05; 25.90 ± 3.86 vs 31.49 ± 5.30, P < 0.05). The birth weights of newborns in the HDCP group and the control group were significantly different (2.52 ± 0.74 vs 3.18 ± 0.41, P < 0.05). The content of Ni in umbilical cord blood in the entire disease group was higher than that in the control group (0.10 ± 0.16 vs 0.05 ± 0.07, P < 0.05). CONCLUSION: In the maternal-fetal system of women with pregnancy complications, the barrier effect of the placenta against Ni is weakened, thus affecting healthy growth of the fetus in the uterus. Baishideng Publishing Group Inc 2021-10-06 2021-10-06 /pmc/articles/PMC8554420/ /pubmed/34754843 http://dx.doi.org/10.12998/wjcc.v9.i28.8340 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Control Study Ding, Ai-Ling Hu, Hong Xu, Fan-Ping Liu, Ling-Yan Peng, Juan Dong, Xu-Dong Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy |
title | Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy |
title_full | Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy |
title_fullStr | Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy |
title_full_unstemmed | Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy |
title_short | Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy |
title_sort | pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy |
topic | Case Control Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554420/ https://www.ncbi.nlm.nih.gov/pubmed/34754843 http://dx.doi.org/10.12998/wjcc.v9.i28.8340 |
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