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Itraconazole therapy for infant hemangioma: Two case reports
BACKGROUND: Infantile hemangiomas (IHs) are the most common childhood benign tumors, showing distinctive progression characteristics and outcomes. Due to the high demand for aesthetics among parents of IH babies, early intervention is critical in some cases. β-Adrenergic blockers and corticosteroids...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554448/ https://www.ncbi.nlm.nih.gov/pubmed/34754871 http://dx.doi.org/10.12998/wjcc.v9.i28.8579 |
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author | Liu, Zhe Lv, Sha Wang, Shuang Qu, Sheng-Ming Zhang, Gui-Yun Lin, Yi-Tong Yang, Lei Li, Fu-Qiu |
author_facet | Liu, Zhe Lv, Sha Wang, Shuang Qu, Sheng-Ming Zhang, Gui-Yun Lin, Yi-Tong Yang, Lei Li, Fu-Qiu |
author_sort | Liu, Zhe |
collection | PubMed |
description | BACKGROUND: Infantile hemangiomas (IHs) are the most common childhood benign tumors, showing distinctive progression characteristics and outcomes. Due to the high demand for aesthetics among parents of IH babies, early intervention is critical in some cases. β-Adrenergic blockers and corticosteroids are first-line medications for IHs, while itraconazole, an antifungal medicine, has shown positive results in recent years. CASE SUMMARY: In the present study, itraconazole was applied to treat two IH cases. The therapeutic course lasted 80-90 d, during which the visible lesion faded by more than 90%. Moreover, no obvious side effects were reported, and the compliance of the baby and parents was desirable. CONCLUSION: Although these outcomes further support itraconazole as an effective therapeutic choice for IHs, large-scale clinical and basic studies are still warranted to improve further treatment. |
format | Online Article Text |
id | pubmed-8554448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-85544482021-11-08 Itraconazole therapy for infant hemangioma: Two case reports Liu, Zhe Lv, Sha Wang, Shuang Qu, Sheng-Ming Zhang, Gui-Yun Lin, Yi-Tong Yang, Lei Li, Fu-Qiu World J Clin Cases Case Report BACKGROUND: Infantile hemangiomas (IHs) are the most common childhood benign tumors, showing distinctive progression characteristics and outcomes. Due to the high demand for aesthetics among parents of IH babies, early intervention is critical in some cases. β-Adrenergic blockers and corticosteroids are first-line medications for IHs, while itraconazole, an antifungal medicine, has shown positive results in recent years. CASE SUMMARY: In the present study, itraconazole was applied to treat two IH cases. The therapeutic course lasted 80-90 d, during which the visible lesion faded by more than 90%. Moreover, no obvious side effects were reported, and the compliance of the baby and parents was desirable. CONCLUSION: Although these outcomes further support itraconazole as an effective therapeutic choice for IHs, large-scale clinical and basic studies are still warranted to improve further treatment. Baishideng Publishing Group Inc 2021-10-06 2021-10-06 /pmc/articles/PMC8554448/ /pubmed/34754871 http://dx.doi.org/10.12998/wjcc.v9.i28.8579 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Liu, Zhe Lv, Sha Wang, Shuang Qu, Sheng-Ming Zhang, Gui-Yun Lin, Yi-Tong Yang, Lei Li, Fu-Qiu Itraconazole therapy for infant hemangioma: Two case reports |
title | Itraconazole therapy for infant hemangioma: Two case reports |
title_full | Itraconazole therapy for infant hemangioma: Two case reports |
title_fullStr | Itraconazole therapy for infant hemangioma: Two case reports |
title_full_unstemmed | Itraconazole therapy for infant hemangioma: Two case reports |
title_short | Itraconazole therapy for infant hemangioma: Two case reports |
title_sort | itraconazole therapy for infant hemangioma: two case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554448/ https://www.ncbi.nlm.nih.gov/pubmed/34754871 http://dx.doi.org/10.12998/wjcc.v9.i28.8579 |
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