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IL-1beta promotes the age-associated decline of beta cell function

Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decreased in islets, whereas IL-1beta gene expression increased sp...

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Detalles Bibliográficos
Autores principales:	Böni-Schnetzler, Marianne, Méreau, Hélène, Rachid, Leila, Wiedemann, Sophia J., Schulze, Friederike, Trimigliozzi, Kelly, Meier, Daniel T., Donath, Marc Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554531/ https://www.ncbi.nlm.nih.gov/pubmed/34746709 http://dx.doi.org/10.1016/j.isci.2021.103250

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