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Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomate...

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Autores principales: Batool, Fareeha, Özçelik, Hayriye, Stutz, Céline, Gegout, Pierre-Yves, Benkirane-Jessel, Nadia, Petit, Catherine, Huck, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554547/
https://www.ncbi.nlm.nih.gov/pubmed/34721831
http://dx.doi.org/10.1177/20417314211041428
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author Batool, Fareeha
Özçelik, Hayriye
Stutz, Céline
Gegout, Pierre-Yves
Benkirane-Jessel, Nadia
Petit, Catherine
Huck, Olivier
author_facet Batool, Fareeha
Özçelik, Hayriye
Stutz, Céline
Gegout, Pierre-Yves
Benkirane-Jessel, Nadia
Petit, Catherine
Huck, Olivier
author_sort Batool, Fareeha
collection PubMed
description Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with the biomaterials through extracellular matrix proteins leading to protein adsorption followed by recruitment, attachment, migration, and proliferation of several immune-inflammatory cells. Physical nanotopography of biomaterials, such as surface proteins, roughness, and porosity, is crucial for driving cellular attachment and migration. Similarly, modification of scaffold surface chemistry by adapting hydrophilicity, surface charge, surface coatings, can down-regulate the initiation of pro-inflammatory cascades. Besides, functionalization of scaffold surfaces with active biological molecules can down-regulate pro-inflammatory and pro-resorptive mediators’ release as well as actively up-regulate anti-inflammatory markers. This review encompasses various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.
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spelling pubmed-85545472021-10-30 Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration Batool, Fareeha Özçelik, Hayriye Stutz, Céline Gegout, Pierre-Yves Benkirane-Jessel, Nadia Petit, Catherine Huck, Olivier J Tissue Eng Review Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with the biomaterials through extracellular matrix proteins leading to protein adsorption followed by recruitment, attachment, migration, and proliferation of several immune-inflammatory cells. Physical nanotopography of biomaterials, such as surface proteins, roughness, and porosity, is crucial for driving cellular attachment and migration. Similarly, modification of scaffold surface chemistry by adapting hydrophilicity, surface charge, surface coatings, can down-regulate the initiation of pro-inflammatory cascades. Besides, functionalization of scaffold surfaces with active biological molecules can down-regulate pro-inflammatory and pro-resorptive mediators’ release as well as actively up-regulate anti-inflammatory markers. This review encompasses various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial. SAGE Publications 2021-10-26 /pmc/articles/PMC8554547/ /pubmed/34721831 http://dx.doi.org/10.1177/20417314211041428 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Batool, Fareeha
Özçelik, Hayriye
Stutz, Céline
Gegout, Pierre-Yves
Benkirane-Jessel, Nadia
Petit, Catherine
Huck, Olivier
Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration
title Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration
title_full Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration
title_fullStr Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration
title_full_unstemmed Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration
title_short Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration
title_sort modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554547/
https://www.ncbi.nlm.nih.gov/pubmed/34721831
http://dx.doi.org/10.1177/20417314211041428
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