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Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis
More and more evidence shows that microRNAs (miRNAs) play an important role in the diagnosis and prognosis of human diseases. In this study, we investigated the diagnostic value of miR-9-5p for asymptomatic carotid artery stenosis (CAS) and its predictive value for future cerebrovascular events with...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554707/ https://www.ncbi.nlm.nih.gov/pubmed/33974530 http://dx.doi.org/10.17305/bjbms.2021.5545 |
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author | Liu, Hongxin Zhou, Juan Jiang, Wei Wang, Feng |
author_facet | Liu, Hongxin Zhou, Juan Jiang, Wei Wang, Feng |
author_sort | Liu, Hongxin |
collection | PubMed |
description | More and more evidence shows that microRNAs (miRNAs) play an important role in the diagnosis and prognosis of human diseases. In this study, we investigated the diagnostic value of miR-9-5p for asymptomatic carotid artery stenosis (CAS) and its predictive value for future cerebrovascular events within 5 years. A total of 88 asymptomatic CAS patients and 86 healthy individuals were recruited. The expression level of serum miR-9-5p was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic value of miR-9-5p in CAS was assessed by a receiving operator characteristic (ROC) curve. The predictive value of miR-9-5p for the occurrence of cerebrovascular events was evaluated by the Kaplan-Meier method. The serum level of miR-9-5p was significantly decreased in asymptomatic CAS patients. ROC curve had an AUC value of 0.910, with the sensitivity and specificity of 80.7% and 87.2% at the cut-off value of 0.72, respectively. A total of 25 patients had cerebrovascular events during the 5-year follow-up, including 3 strokes and 22 transient ischemic attacks (TIAs). Kaplan-Meier survival analysis revealed that the low expression level of miR-9-5p was an independent factor closely related to the occurrence of cerebrovascular events. Serum miR-9-5p could be used as a new biomarker for the diagnosis of CAS, and the low expression of miR-9-5p is associated with poor prognosis. |
format | Online Article Text |
id | pubmed-8554707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
record_format | MEDLINE/PubMed |
spelling | pubmed-85547072021-12-01 Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis Liu, Hongxin Zhou, Juan Jiang, Wei Wang, Feng Bosn J Basic Med Sci Research Article More and more evidence shows that microRNAs (miRNAs) play an important role in the diagnosis and prognosis of human diseases. In this study, we investigated the diagnostic value of miR-9-5p for asymptomatic carotid artery stenosis (CAS) and its predictive value for future cerebrovascular events within 5 years. A total of 88 asymptomatic CAS patients and 86 healthy individuals were recruited. The expression level of serum miR-9-5p was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic value of miR-9-5p in CAS was assessed by a receiving operator characteristic (ROC) curve. The predictive value of miR-9-5p for the occurrence of cerebrovascular events was evaluated by the Kaplan-Meier method. The serum level of miR-9-5p was significantly decreased in asymptomatic CAS patients. ROC curve had an AUC value of 0.910, with the sensitivity and specificity of 80.7% and 87.2% at the cut-off value of 0.72, respectively. A total of 25 patients had cerebrovascular events during the 5-year follow-up, including 3 strokes and 22 transient ischemic attacks (TIAs). Kaplan-Meier survival analysis revealed that the low expression level of miR-9-5p was an independent factor closely related to the occurrence of cerebrovascular events. Serum miR-9-5p could be used as a new biomarker for the diagnosis of CAS, and the low expression of miR-9-5p is associated with poor prognosis. Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021-12 /pmc/articles/PMC8554707/ /pubmed/33974530 http://dx.doi.org/10.17305/bjbms.2021.5545 Text en Copyright: © The Author(s) (2021) https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Research Article Liu, Hongxin Zhou, Juan Jiang, Wei Wang, Feng Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis |
title | Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis |
title_full | Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis |
title_fullStr | Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis |
title_full_unstemmed | Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis |
title_short | Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis |
title_sort | analysis of the diagnostic and prognostic value of mir-9-5p in carotid artery stenosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554707/ https://www.ncbi.nlm.nih.gov/pubmed/33974530 http://dx.doi.org/10.17305/bjbms.2021.5545 |
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