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Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis

More and more evidence shows that microRNAs (miRNAs) play an important role in the diagnosis and prognosis of human diseases. In this study, we investigated the diagnostic value of miR-9-5p for asymptomatic carotid artery stenosis (CAS) and its predictive value for future cerebrovascular events with...

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Autores principales: Liu, Hongxin, Zhou, Juan, Jiang, Wei, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554707/
https://www.ncbi.nlm.nih.gov/pubmed/33974530
http://dx.doi.org/10.17305/bjbms.2021.5545
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author Liu, Hongxin
Zhou, Juan
Jiang, Wei
Wang, Feng
author_facet Liu, Hongxin
Zhou, Juan
Jiang, Wei
Wang, Feng
author_sort Liu, Hongxin
collection PubMed
description More and more evidence shows that microRNAs (miRNAs) play an important role in the diagnosis and prognosis of human diseases. In this study, we investigated the diagnostic value of miR-9-5p for asymptomatic carotid artery stenosis (CAS) and its predictive value for future cerebrovascular events within 5 years. A total of 88 asymptomatic CAS patients and 86 healthy individuals were recruited. The expression level of serum miR-9-5p was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic value of miR-9-5p in CAS was assessed by a receiving operator characteristic (ROC) curve. The predictive value of miR-9-5p for the occurrence of cerebrovascular events was evaluated by the Kaplan-Meier method. The serum level of miR-9-5p was significantly decreased in asymptomatic CAS patients. ROC curve had an AUC value of 0.910, with the sensitivity and specificity of 80.7% and 87.2% at the cut-off value of 0.72, respectively. A total of 25 patients had cerebrovascular events during the 5-year follow-up, including 3 strokes and 22 transient ischemic attacks (TIAs). Kaplan-Meier survival analysis revealed that the low expression level of miR-9-5p was an independent factor closely related to the occurrence of cerebrovascular events. Serum miR-9-5p could be used as a new biomarker for the diagnosis of CAS, and the low expression of miR-9-5p is associated with poor prognosis.
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spelling pubmed-85547072021-12-01 Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis Liu, Hongxin Zhou, Juan Jiang, Wei Wang, Feng Bosn J Basic Med Sci Research Article More and more evidence shows that microRNAs (miRNAs) play an important role in the diagnosis and prognosis of human diseases. In this study, we investigated the diagnostic value of miR-9-5p for asymptomatic carotid artery stenosis (CAS) and its predictive value for future cerebrovascular events within 5 years. A total of 88 asymptomatic CAS patients and 86 healthy individuals were recruited. The expression level of serum miR-9-5p was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic value of miR-9-5p in CAS was assessed by a receiving operator characteristic (ROC) curve. The predictive value of miR-9-5p for the occurrence of cerebrovascular events was evaluated by the Kaplan-Meier method. The serum level of miR-9-5p was significantly decreased in asymptomatic CAS patients. ROC curve had an AUC value of 0.910, with the sensitivity and specificity of 80.7% and 87.2% at the cut-off value of 0.72, respectively. A total of 25 patients had cerebrovascular events during the 5-year follow-up, including 3 strokes and 22 transient ischemic attacks (TIAs). Kaplan-Meier survival analysis revealed that the low expression level of miR-9-5p was an independent factor closely related to the occurrence of cerebrovascular events. Serum miR-9-5p could be used as a new biomarker for the diagnosis of CAS, and the low expression of miR-9-5p is associated with poor prognosis. Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021-12 /pmc/articles/PMC8554707/ /pubmed/33974530 http://dx.doi.org/10.17305/bjbms.2021.5545 Text en Copyright: © The Author(s) (2021) https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Research Article
Liu, Hongxin
Zhou, Juan
Jiang, Wei
Wang, Feng
Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis
title Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis
title_full Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis
title_fullStr Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis
title_full_unstemmed Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis
title_short Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis
title_sort analysis of the diagnostic and prognostic value of mir-9-5p in carotid artery stenosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554707/
https://www.ncbi.nlm.nih.gov/pubmed/33974530
http://dx.doi.org/10.17305/bjbms.2021.5545
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