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Storing and Reading Information in Mixtures of Fluorescent Molecules
[Image: see text] The rapidly increasing use of digital technologies requires the rethinking of methods to store data. This work shows that digital data can be stored in mixtures of fluorescent dye molecules, which are deposited on a surface by inkjet printing, where an amide bond tethers the dye mo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554834/ https://www.ncbi.nlm.nih.gov/pubmed/34729416 http://dx.doi.org/10.1021/acscentsci.1c00728 |
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author | Nagarkar, Amit A. Root, Samuel E. Fink, Michael J. Ten, Alexei S. Cafferty, Brian J. Richardson, Douglas S. Mrksich, Milan Whitesides, George M. |
author_facet | Nagarkar, Amit A. Root, Samuel E. Fink, Michael J. Ten, Alexei S. Cafferty, Brian J. Richardson, Douglas S. Mrksich, Milan Whitesides, George M. |
author_sort | Nagarkar, Amit A. |
collection | PubMed |
description | [Image: see text] The rapidly increasing use of digital technologies requires the rethinking of methods to store data. This work shows that digital data can be stored in mixtures of fluorescent dye molecules, which are deposited on a surface by inkjet printing, where an amide bond tethers the dye molecules to the surface. A microscope equipped with a multichannel fluorescence detector distinguishes individual dyes in the mixture. The presence or absence of these molecules in the mixture encodes binary information (i.e., “0” or “1”). The use of mixtures of molecules, instead of sequence-defined macromolecules, minimizes the time and difficulty of synthesis and eliminates the requirement of sequencing. We have written, stored, and read a total of approximately 400 kilobits (both text and images) with greater than 99% recovery of information, written at an average rate of 128 bits/s (16 bytes/s) and read at a rate of 469 bits/s (58.6 bytes/s). |
format | Online Article Text |
id | pubmed-8554834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-85548342021-11-01 Storing and Reading Information in Mixtures of Fluorescent Molecules Nagarkar, Amit A. Root, Samuel E. Fink, Michael J. Ten, Alexei S. Cafferty, Brian J. Richardson, Douglas S. Mrksich, Milan Whitesides, George M. ACS Cent Sci [Image: see text] The rapidly increasing use of digital technologies requires the rethinking of methods to store data. This work shows that digital data can be stored in mixtures of fluorescent dye molecules, which are deposited on a surface by inkjet printing, where an amide bond tethers the dye molecules to the surface. A microscope equipped with a multichannel fluorescence detector distinguishes individual dyes in the mixture. The presence or absence of these molecules in the mixture encodes binary information (i.e., “0” or “1”). The use of mixtures of molecules, instead of sequence-defined macromolecules, minimizes the time and difficulty of synthesis and eliminates the requirement of sequencing. We have written, stored, and read a total of approximately 400 kilobits (both text and images) with greater than 99% recovery of information, written at an average rate of 128 bits/s (16 bytes/s) and read at a rate of 469 bits/s (58.6 bytes/s). American Chemical Society 2021-10-13 2021-10-27 /pmc/articles/PMC8554834/ /pubmed/34729416 http://dx.doi.org/10.1021/acscentsci.1c00728 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Nagarkar, Amit A. Root, Samuel E. Fink, Michael J. Ten, Alexei S. Cafferty, Brian J. Richardson, Douglas S. Mrksich, Milan Whitesides, George M. Storing and Reading Information in Mixtures of Fluorescent Molecules |
title | Storing and Reading Information in Mixtures of Fluorescent
Molecules |
title_full | Storing and Reading Information in Mixtures of Fluorescent
Molecules |
title_fullStr | Storing and Reading Information in Mixtures of Fluorescent
Molecules |
title_full_unstemmed | Storing and Reading Information in Mixtures of Fluorescent
Molecules |
title_short | Storing and Reading Information in Mixtures of Fluorescent
Molecules |
title_sort | storing and reading information in mixtures of fluorescent
molecules |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554834/ https://www.ncbi.nlm.nih.gov/pubmed/34729416 http://dx.doi.org/10.1021/acscentsci.1c00728 |
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