Ischemic Stroke and Sleep: The Linking Genetic Factors

This review summarizes the available data about genetic factors which can link ischemic stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by heritability and comprise up to 38–46%. According to Mendelian randomization analysis, genetic liability for short sleep d...

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Autor principal: Korostovtseva, Lyudmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555086/
https://www.ncbi.nlm.nih.gov/pubmed/34191267
http://dx.doi.org/10.1007/s40119-021-00231-9
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author Korostovtseva, Lyudmila
author_facet Korostovtseva, Lyudmila
author_sort Korostovtseva, Lyudmila
collection PubMed
description This review summarizes the available data about genetic factors which can link ischemic stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by heritability and comprise up to 38–46%. According to Mendelian randomization analysis, genetic liability for short sleep duration and frequent insomnia symptoms is associated with ischemic stroke (predominantly of large artery subtype). The potential genetic links include variants of circadian genes, genes encoding components of neurotransmitter systems, common cardiovascular risk factors, as well as specific genetic factors related to certain sleep disorders.
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spelling pubmed-85550862021-11-10 Ischemic Stroke and Sleep: The Linking Genetic Factors Korostovtseva, Lyudmila Cardiol Ther Review This review summarizes the available data about genetic factors which can link ischemic stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by heritability and comprise up to 38–46%. According to Mendelian randomization analysis, genetic liability for short sleep duration and frequent insomnia symptoms is associated with ischemic stroke (predominantly of large artery subtype). The potential genetic links include variants of circadian genes, genes encoding components of neurotransmitter systems, common cardiovascular risk factors, as well as specific genetic factors related to certain sleep disorders. Springer Healthcare 2021-06-30 2021-12 /pmc/articles/PMC8555086/ /pubmed/34191267 http://dx.doi.org/10.1007/s40119-021-00231-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Korostovtseva, Lyudmila
Ischemic Stroke and Sleep: The Linking Genetic Factors
title Ischemic Stroke and Sleep: The Linking Genetic Factors
title_full Ischemic Stroke and Sleep: The Linking Genetic Factors
title_fullStr Ischemic Stroke and Sleep: The Linking Genetic Factors
title_full_unstemmed Ischemic Stroke and Sleep: The Linking Genetic Factors
title_short Ischemic Stroke and Sleep: The Linking Genetic Factors
title_sort ischemic stroke and sleep: the linking genetic factors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555086/
https://www.ncbi.nlm.nih.gov/pubmed/34191267
http://dx.doi.org/10.1007/s40119-021-00231-9
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