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Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE)

BACKGROUND: To investigate the safety and efficacy of 8Spheres in partial splenic embolization. To explore the possibility of accurate control of splenic embolic volume by quantifying the number of microspheres used during PSE. METHOD: The data of 179 patients who underwent PSE were collected. The p...

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Autores principales: Lu, Haohao, Zheng, Chuansheng, Liang, Bin, Xiong, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555096/
https://www.ncbi.nlm.nih.gov/pubmed/34706678
http://dx.doi.org/10.1186/s12876-021-01991-3
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author Lu, Haohao
Zheng, Chuansheng
Liang, Bin
Xiong, Bin
author_facet Lu, Haohao
Zheng, Chuansheng
Liang, Bin
Xiong, Bin
author_sort Lu, Haohao
collection PubMed
description BACKGROUND: To investigate the safety and efficacy of 8Spheres in partial splenic embolization. To explore the possibility of accurate control of splenic embolic volume by quantifying the number of microspheres used during PSE. METHOD: The data of 179 patients who underwent PSE were collected. The patients were divided into two groups: 300–500 um microsphere group (N = 83) and 500–700 um microsphere group (N = 96). The spleen volume before PSE, infarct volume and infarct rate of the spleen after PSE, changes in peripheral blood cells after PSE, postoperative adverse events and incidence of infection were compared between the two groups. RESULTS: 300–500 um group vs 500–700 um group: postoperative spleen volume (cm(3)): 753.82 ± 325.41 vs 568.65 ± 298.16 (P = 0.008); spleen embolization volume (cm(3)): 525.93 ± 118.29 vs 630.26 ± 109.71 (P = 0.014); spleen embolization rate: 41.1 ± 12.3% vs 52.4 ± 10.1% (P = 0.021). Leukocytes and platelets were significantly increased after PSE in both groups; leukocyte, 1 month: 4.13 ± 0.91 vs 5.08 ± 1.16 (P = 0.026); 3 months: 4.08 ± 1.25 vs 4.83 ± 0.98 (P = 0.022); platelet, 1 month: 125.6 ± 20.3 vs 138.7 ± 18.4 (P = 0.019); 3 months: 121.8 ± 16.9 vs 134.3 ± 20.1 (P = 0.017). Incidence of abdominal pain after PSE, 72 (86.7%) vs 69 (71.9%), P = 0.027. The incidence of other adverse events and infections after PSE was not statistically different. CONCLUSION: PSE with 8Spheres is safe and effective. The use of 500–700 um microsphere for PSE can make the increase of peripheral blood cells more stable. Each vial of 8Spheres corresponds to a certain volume of splenic embolization, so it is possible to achieve quantitative embolization in PSE.
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spelling pubmed-85550962021-10-29 Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE) Lu, Haohao Zheng, Chuansheng Liang, Bin Xiong, Bin BMC Gastroenterol Research BACKGROUND: To investigate the safety and efficacy of 8Spheres in partial splenic embolization. To explore the possibility of accurate control of splenic embolic volume by quantifying the number of microspheres used during PSE. METHOD: The data of 179 patients who underwent PSE were collected. The patients were divided into two groups: 300–500 um microsphere group (N = 83) and 500–700 um microsphere group (N = 96). The spleen volume before PSE, infarct volume and infarct rate of the spleen after PSE, changes in peripheral blood cells after PSE, postoperative adverse events and incidence of infection were compared between the two groups. RESULTS: 300–500 um group vs 500–700 um group: postoperative spleen volume (cm(3)): 753.82 ± 325.41 vs 568.65 ± 298.16 (P = 0.008); spleen embolization volume (cm(3)): 525.93 ± 118.29 vs 630.26 ± 109.71 (P = 0.014); spleen embolization rate: 41.1 ± 12.3% vs 52.4 ± 10.1% (P = 0.021). Leukocytes and platelets were significantly increased after PSE in both groups; leukocyte, 1 month: 4.13 ± 0.91 vs 5.08 ± 1.16 (P = 0.026); 3 months: 4.08 ± 1.25 vs 4.83 ± 0.98 (P = 0.022); platelet, 1 month: 125.6 ± 20.3 vs 138.7 ± 18.4 (P = 0.019); 3 months: 121.8 ± 16.9 vs 134.3 ± 20.1 (P = 0.017). Incidence of abdominal pain after PSE, 72 (86.7%) vs 69 (71.9%), P = 0.027. The incidence of other adverse events and infections after PSE was not statistically different. CONCLUSION: PSE with 8Spheres is safe and effective. The use of 500–700 um microsphere for PSE can make the increase of peripheral blood cells more stable. Each vial of 8Spheres corresponds to a certain volume of splenic embolization, so it is possible to achieve quantitative embolization in PSE. BioMed Central 2021-10-27 /pmc/articles/PMC8555096/ /pubmed/34706678 http://dx.doi.org/10.1186/s12876-021-01991-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lu, Haohao
Zheng, Chuansheng
Liang, Bin
Xiong, Bin
Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE)
title Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE)
title_full Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE)
title_fullStr Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE)
title_full_unstemmed Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE)
title_short Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE)
title_sort quantitative splenic embolization possible: application of 8spheres conformal microspheres in partial splenic embolization (pse)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555096/
https://www.ncbi.nlm.nih.gov/pubmed/34706678
http://dx.doi.org/10.1186/s12876-021-01991-3
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