Residues T(48) and A(49) in HIV-1 NL4-3 Nef are responsible for the counteraction of autophagy initiation, which prevents the ubiquitin-dependent degradation of Gag through autophagosomes

BACKGROUND: Autophagy plays an important role as a cellular defense mechanism against intracellular pathogens, like viruses. Specifically, autophagy orchestrates the recruitment of specialized cargo, including viral components needed for replication, for lysosomal degradation. In addition to this pr...

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Detalles Bibliográficos
Autores principales: Castro-Gonzalez, Sergio, Chen, Yuexuan, Benjamin, Jared, Shi, Yuhang, Serra-Moreno, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555152/
https://www.ncbi.nlm.nih.gov/pubmed/34711257
http://dx.doi.org/10.1186/s12977-021-00576-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555152/
https://www.ncbi.nlm.nih.gov/pubmed/34711257
http://dx.doi.org/10.1186/s12977-021-00576-y

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