Cargando…

The impact of blood transcriptomic biomarker targeted tuberculosis preventive therapy in people living with HIV: a mathematical modelling study

BACKGROUND: Tuberculosis (TB) preventive therapy is recommended for all people living with HIV (PLHIV). Despite the elevated risk of TB amongst PLHIV, most of those eligible for preventive therapy would never develop TB. Tests which can identify individuals at greatest risk of disease would allow mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sumner, Tom, Mendelsohn, Simon C., Scriba, Thomas J., Hatherill, Mark, White, Richard G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555196/ https://www.ncbi.nlm.nih.gov/pubmed/34711213 http://dx.doi.org/10.1186/s12916-021-02127-w

Ejemplares similares

Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol
por: Mendelsohn, Simon C, et al.
Publicado: (2021)

Systematic review of diagnostic and prognostic host blood transcriptomic signatures of tuberculosis disease in people living with HIV
por: Mendelsohn, Simon C, et al.
Publicado: (2023)

Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study
por: Mendelsohn, Simon C, et al.
Publicado: (2021)

Blood transcriptional signatures for tuberculosis testing
por: Mendelsohn, Simon C, et al.
Publicado: (2020)

Potential population level impact on tuberculosis incidence of using an mRNA expression signature correlate-of-risk test to target tuberculosis preventive therapy
por: Sumner, Tom, et al.
Publicado: (2019)

Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol
por: Mulenga, Humphrey, et al.
Publicado: (2019)

Performance of diagnostic and predictive host blood transcriptomic signatures for Tuberculosis disease: A systematic review and meta-analysis
por: Mulenga, Humphrey, et al.
Publicado: (2020)

Prospective multicentre head-to-head validation of host blood transcriptomic biomarkers for pulmonary tuberculosis by real-time PCR
por: Mendelsohn, Simon C., et al.
Publicado: (2022)

Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial
por: Scriba, Thomas J, et al.
Publicado: (2021)

Clinical predictors of pulmonary tuberculosis among South African adults with HIV
por: Mendelsohn, Simon C., et al.
Publicado: (2022)

The effect of host factors on discriminatory performance of a transcriptomic signature of tuberculosis risk
por: Mulenga, Humphrey, et al.
Publicado: (2022)

Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis
por: Petruccioli, Elisa, et al.
Publicado: (2016)

Headway made towards biosignatures for incipient tuberculosis
por: Scriba, Thomas J, et al.
Publicado: (2020)

Considerations for biomarker-targeted intervention strategies for tuberculosis disease prevention
por: Fiore-Gartland, Andrew, et al.
Publicado: (2018)

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
por: Mulenga, Humphrey, et al.
Publicado: (2021)

Mycobacterium tuberculosis infection, immune activation, and risk of HIV acquisition
por: Bender Ignacio, Rachel A., et al.
Publicado: (2022)

Evaluation of a transcriptomic signature of tuberculosis risk in combination with an interferon gamma release assay: A diagnostic test accuracy study
por: Mulenga, Humphrey, et al.
Publicado: (2022)

New opportunities in tuberculosis prevention: implications for people living with HIV
por: González Fernández, Lucia, et al.
Publicado: (2020)

Regional changes in tuberculosis disease burden among adolescents in South Africa (2005–2015)
por: Bunyasi, Erick Wekesa, et al.
Publicado: (2020)

The predicted impact of tuberculosis preventive therapy: the importance of disease progression assumptions
por: Sumner, Tom, et al.
Publicado: (2020)

Acceptability of Community-Based Tuberculosis Preventive Treatment for People Living with HIV in Zimbabwe
por: Msukwa, Martin K., et al.
Publicado: (2022)

Isoniazid prophylaxis: highly effective but underutilised to prevent tuberculosis in people living with HIV
por: Vojnov, Lara, et al.
Publicado: (2022)

Diagnostic performance of blood inflammatory markers for tuberculosis screening in people living with HIV
por: Farr, Katherine, et al.
Publicado: (2018)

Detection of Tuberculosis Recurrence, Diagnosis and Treatment Response by a Blood Transcriptomic Risk Signature in HIV-Infected Persons on Antiretroviral Therapy
por: Darboe, Fatoumatta, et al.
Publicado: (2019)

Tuberculosis control in people living with HIV/AIDS
por: Magnabosco, Gabriela Tavares, et al.
Publicado: (2016)

Risk of Disease After Isoniazid Preventive Therapy for Mycobacterium tuberculosis Exposure in Young HIV-uninfected Children
por: Luabeya, Kany Kany A., et al.
Publicado: (2015)

Tuberculosis preventive treatment in people living with HIV—Is the glass half empty or half full?
por: Oxlade, Olivia, et al.
Publicado: (2021)

Multidimensional analysis of immune responses identified biomarkers of recent Mycobacterium tuberculosis infection
por: Lloyd, Tessa, et al.
Publicado: (2021)

Evaluation of the uptake of tuberculosis preventative therapy for people living with HIV in Namibia: a multiple methods analysis
por: Roscoe, Clay, et al.
Publicado: (2020)

Blood RNA biomarkers for tuberculosis screening in people living with HIV prior to anti-retroviral therapy initiation: A diagnostic accuracy study
por: Mann, Tiffeney, et al.
Publicado: (2023)

Tuberculosis Control in South African Gold Mines: Mathematical Modeling of a Trial of Community-Wide Isoniazid Preventive Therapy
por: Vynnycky, Emilia, et al.
Publicado: (2015)

Transcriptomics for child and adolescent tuberculosis
por: Kaforou, Myrsini, et al.
Publicado: (2022)

Tuberculosis preventive therapy for people living with HIV: A systematic review and network meta-analysis
por: Yanes-Lane, Mercedes, et al.
Publicado: (2021)

Plasma host protein biomarkers correlating with increasing Mycobacterium tuberculosis infection activity prior to tuberculosis diagnosis in people living with HIV
por: Singer, Sarah N., et al.
Publicado: (2021)

Isoniazid Preventive Therapy for Prevention of Tuberculosis among People Living with HIV in Ethiopia: A Systematic Review of Implementation and Impacts
por: Assefa, Dawit Getachew, et al.
Publicado: (2022)

Beneficial Effect of Isoniazid Preventive Therapy and Antiretroviral Therapy on the Incidence of Tuberculosis in People Living with HIV in Ethiopia
por: Yirdaw, Kesetebirhan Delele, et al.
Publicado: (2014)

Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe
por: Nyathi, Saziso, et al.
Publicado: (2019)

Isoniazid Preventive Therapy for Tuberculosis in People Living with HIV: A Cross Sectional Study in Butebo, Uganda
por: Oonyu, Lawrence, et al.
Publicado: (2022)

Preferences of people living with HIV for features of tuberculosis preventive treatment regimens – a discrete choice experiment
por: Aschmann, Hélène E., et al.
Publicado: (2023)

Diagnostic Accuracy Study of a Novel Blood-Based Assay for Identification of Tuberculosis in People Living with HIV
por: Södersten, Erik, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_767i416cvmkr0fqvhess0e2tph