Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer

BACKGROUND: Colorectal cancer is known to be resistant to immune checkpoint blockade (ICB) therapy. Sonodynamic therapy (SDT) has been reported to improve the efficacy of immunotherapy by inducing immunogenic cell death (ICD) of cancer. However, the SDT efficacy is extremely limited by Nrf2-based na...

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Detalles Bibliográficos
Autores principales: Wan, Guoyun, Chen, Xuheng, Wang, Haijiao, Hou, Shenglei, Wang, Qian, Cheng, Yuanyuan, Chen, Qian, Lv, Yingge, Chen, Hongli, Zhang, Qiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555306/
https://www.ncbi.nlm.nih.gov/pubmed/34715867
http://dx.doi.org/10.1186/s12951-021-01094-x

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