Cargando…

Functional drug–target–disease network analysis of gene–phenotype connectivity for curcumin in hepatocellular carcinoma

BACKGROUND: The anti-tumor properties of curcumin have been demonstrated for many types of cancer. However, a systematic functional and biological analysis of its target proteins has yet to be fully documented. The aim of this study was to explore the underlying mechanisms of curcumin and broaden th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Yuanyuan, Tao, Jiahao, Chen, Zhuangzhong, Li, Suihui, Liu, Zeyu, Lin, Lizhu, Zhai, Linzhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2021
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555505/ https://www.ncbi.nlm.nih.gov/pubmed/34754622 http://dx.doi.org/10.7717/peerj.12339

Ejemplares similares

Identification of gene-phenotype connectivity associated with flavanone naringenin by functional network analysis
por: Fu, Suhong, et al.
Publicado: (2019)

Development and External Validation of a Nomogram to Predict Cancer-Specific Survival in Patients with Primary Intestinal Non-Hodgkin Lymphomas
por: Zhang, Cuifen, et al.
Publicado: (2021)

Determining novel candidate anti-hepatocellular carcinoma drugs using interaction networks and molecular docking between drug targets and natural compounds of SiNiSan
por: Zhang, Qin, et al.
Publicado: (2021)

Construction of a competing endogenous RNA network to analyse glucose-6-phosphate dehydrogenase dysregulation in hepatocellular carcinoma
por: Wang, Pengyu, et al.
Publicado: (2022)

Analysis of ceRNA networks and identification of potential drug targets for drug-resistant leukemia cell K562/ADR
por: Liu, Zhaoping, et al.
Publicado: (2021)

The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database
por: Zhang, Cuifen, et al.
Publicado: (2021)

Potential targets and molecular mechanism of miR-331-3p in hepatocellular carcinoma identified by weighted gene coexpression network analysis
por: Chi, Qingjia, et al.
Publicado: (2020)

Active ingredients and molecular targets of Taraxacum mongolicum against hepatocellular carcinoma: network pharmacology, molecular docking, and molecular dynamics simulation analysis
por: Zheng, Yanfeng, et al.
Publicado: (2022)

Single-cell transcriptomics analysis reveals intratumoral heterogeneity and identifies a gene signature associated with prognosis of hepatocellular carcinoma
por: Liang, Jialu, et al.
Publicado: (2022)

Identification of key genes and long non-coding RNA associated ceRNA networks in hepatocellular carcinoma
por: Liu, Jun, et al.
Publicado: (2019)

First-line treatments for patients with advanced ALK gene rearrangements in NSCLC: a systematic review and network meta-analysis
por: Tao, Jiahao, et al.
Publicado: (2022)

A novel fatty acid metabolism-related gene prognostic signature and candidate drugs for patients with hepatocellular carcinoma
por: Yang, Jingze, et al.
Publicado: (2023)

Identification of four prognostic LncRNAs for survival prediction of patients with hepatocellular carcinoma
por: Wang, Zhonghao, et al.
Publicado: (2017)

Construction and Comprehensive Analysis of ceRNA Networks and Tumor-Infiltrating Immune Cells in Hepatocellular Carcinoma With Vascular Invasion
por: Cai, Shijiao, et al.
Publicado: (2022)

Identification and validation of ADME genes as prognosis and therapy markers for hepatocellular carcinoma patients
por: Wang, Jukun, et al.
Publicado: (2021)

Construction and analysis of macrophage infiltration related circRNA-miRNA-mRNA regulatory networks in hepatocellular carcinoma
por: Chen, Yuhan, et al.
Publicado: (2020)

Co-expression analysis and ceRNA network reveal eight novel potential lncRNA biomarkers in hepatocellular carcinoma
por: Zou, Ren-chao, et al.
Publicado: (2019)

mRNA expression profile analysis reveals a C-MYC/miR-34a pathway involved in the apoptosis of diffuse large B-cell lymphoma cells induced by Yiqichutan treatment
por: Zhai, Linzhu, et al.
Publicado: (2020)

A genomic-clinical nomogram predicting recurrence-free survival for patients diagnosed with hepatocellular carcinoma
por: Kong, Junjie, et al.
Publicado: (2019)

DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma
por: Ju, Gaoda, et al.
Publicado: (2021)

A novel DNA methylation-based model that effectively predicts prognosis in hepatocellular carcinoma
por: Hao, Xiang-Yong, et al.
Publicado: (2021)

Integrative analysis of dysregulated lncRNA-associated ceRNA network reveals potential lncRNA biomarkers for human hepatocellular carcinoma
por: Li, Chengyun, et al.
Publicado: (2020)

INK4 cyclin-dependent kinase inhibitors as potential prognostic biomarkers and therapeutic targets in hepatocellular carcinoma
por: Liu, Hui, et al.
Publicado: (2022)

The potential, analysis and prospect of ctDNA sequencing in hepatocellular carcinoma
por: Ding, Yubo, et al.
Publicado: (2022)

Downregulation of miR-193a-3p is involved in the pathogenesis of hepatocellular carcinoma by targeting CCND1
por: Wang, Shi-shuo, et al.
Publicado: (2020)

Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma
por: Huang, Runzhi, et al.
Publicado: (2020)

Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma
por: Yang, Xiaolin, et al.
Publicado: (2020)

Development and validation of ferroptosis-related lncRNAs signature for hepatocellular carcinoma
por: Liang, Jiaying, et al.
Publicado: (2021)

Upregulated TUBG1 expression is correlated with poor prognosis in hepatocellular carcinoma
por: Zhang, Kainan, et al.
Publicado: (2022)

Connecting the dots: A practical evaluation of web-tools for describing protein dynamics as networks
por: Petrizzelli, Francesco, et al.
Publicado: (2022)

Network science meets respiratory medicine for OSAS phenotyping and severity prediction
por: Mihaicuta, Stefan, et al.
Publicado: (2017)

Identification of crucial genes based on expression profiles of hepatocellular carcinomas by bioinformatics analysis
por: Liu, Ze-Kun, et al.
Publicado: (2019)

Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma
por: Tang, Chaozhi, et al.
Publicado: (2020)

Identification of hepatocellular carcinoma prognostic markers based on 10-immune gene signature
por: Zhao, Kaifei, et al.
Publicado: (2020)

DPM1 expression as a potential prognostic tumor marker in hepatocellular carcinoma
por: Li, Ming, et al.
Publicado: (2020)

Transcriptome analysis revealed key prognostic genes and microRNAs in hepatocellular carcinoma
por: Ma, Xi, et al.
Publicado: (2020)

Bioinformatics profiling identifies seven immune-related risk signatures for hepatocellular carcinoma
por: Xue, Feng, et al.
Publicado: (2020)

Comprehensive analysis reveals a metabolic ten-gene signature in hepatocellular carcinoma
por: Zhu, Zhipeng, et al.
Publicado: (2020)

Prognostic implications of cell division cycle protein 45 expression in hepatocellular carcinoma
por: Yang, Chen, et al.
Publicado: (2021)

Identification of hub genes and biological pathways in hepatocellular carcinoma by integrated bioinformatics analysis
por: Zhao, Qian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hr2iaj07stuhsvu9m3u37hpmt0