Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers

γδ T lymphocytes diverge from conventional T CD8 lymphocytes for ontogeny, homing, and antigen specificity, but whether their differentiation in tumors also deviates was unknown. Using innovative analyses of our original and ~150 published single-cell RNA sequencing datasets validated by phenotyping...

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Detalles Bibliográficos
Autores principales: Cerapio, Juan-Pablo, Perrier, Marion, Balança, Camille-Charlotte, Gravelle, Pauline, Pont, Fréderic, Devaud, Christel, Franchini, Don-Marc, Féliu, Virginie, Tosolini, Marie, Valle, Carine, Lopez, Fréderic, Quillet-Mary, Anne, Ysebaert, Loic, Martinez, Alejandra, Delord, Jean Pierre, Ayyoub, Maha, Laurent, Camille, Fournie, Jean-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555559/
https://www.ncbi.nlm.nih.gov/pubmed/34721945
http://dx.doi.org/10.1080/2162402X.2021.1939518

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