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Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study

BACKGROUND & OBJECTIVES: India witnessed a massive second surge of COVID-19 cases since March 2021 after a period of decline from September 2020. Data collected under the National Clinical Registry for COVID-19 (NCRC) were analysed to describe the differences in demographic and clinical features...

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Autores principales: Kumar, Gunjan, Mukherjee, Aparna, Sharma, Ravendra K., Menon, Geetha R., Sahu, Damodar, Wig, Naveet, Panda, Samiran, Rao, Vishnu Vardhan, Singh, Sujeet, Guleria, Randeep, Bhargava, Balram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555588/
https://www.ncbi.nlm.nih.gov/pubmed/34259194
http://dx.doi.org/10.4103/ijmr.ijmr_1628_21
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author Kumar, Gunjan
Mukherjee, Aparna
Sharma, Ravendra K.
Menon, Geetha R.
Sahu, Damodar
Wig, Naveet
Panda, Samiran
Rao, Vishnu Vardhan
Singh, Sujeet
Guleria, Randeep
Bhargava, Balram
author_facet Kumar, Gunjan
Mukherjee, Aparna
Sharma, Ravendra K.
Menon, Geetha R.
Sahu, Damodar
Wig, Naveet
Panda, Samiran
Rao, Vishnu Vardhan
Singh, Sujeet
Guleria, Randeep
Bhargava, Balram
author_sort Kumar, Gunjan
collection PubMed
description BACKGROUND & OBJECTIVES: India witnessed a massive second surge of COVID-19 cases since March 2021 after a period of decline from September 2020. Data collected under the National Clinical Registry for COVID-19 (NCRC) were analysed to describe the differences in demographic and clinical features of COVID-19 patients recruited during these two successive waves. METHODS: The NCRC, launched in September 2020, is an ongoing multicentre observational initiative, which provided the platform for the current investigation. Demographic, clinical, treatment and outcome data of hospitalized, confirmed COVID-19 patients were captured in an electronic data portal from 41 hospitals across India. Patients enrolled during September 1, 2020 to January 31, 2021 and February 1 to May 11, 2021 constituted participants of the two successive waves, respectively. RESULTS: As on May 11, 2021, 18961 individuals were recruited in the registry, 12059 and 6903 reflecting in-patients from the first and second waves, respectively. Mean age of the patients was significantly lower in the second wave [48.7 (18.1) yr vs. 50.7 (18.0) yr, P<0.001] with higher proportion of patients in the younger age group intervals of <20, and 20-39 yr. Approximately 70 per cent of the admitted patients were ≥ 40 yr of age in both waves of the pandemic. The proportion of males were slightly lower in second wave as compared to the first [4400 (63.7%) vs. 7886 (65.4%), P=0.02]. Commonest presenting symptom was fever in both waves. In the second wave, a significantly higher proportion [2625 (48.6%) vs. 4420 (42.8%), P<0.003] complained of shortness of breath, developed ARDS [422(13%) vs. 880 (7.9%), P<0.001], required supplemental oxygen [1637 (50.3%) vs. 4771 (42.7%), P<0.001], and mechanical ventilation [260 (15.9%) vs. 530 (11.1%), P<0.001]. Mortality also significantly increased in the second wave [OR: 1.35 (95% CI: 1.19, 1.52)] in all age groups except in <20 yr. INTERPRETATION & CONCLUSIONS: The second wave of COVID-19 in India was slightly different in presentation than the first wave, with a younger demography, lesser comorbidities, and presentation with breathlessness in greater frequency.
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spelling pubmed-85555882021-11-09 Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study Kumar, Gunjan Mukherjee, Aparna Sharma, Ravendra K. Menon, Geetha R. Sahu, Damodar Wig, Naveet Panda, Samiran Rao, Vishnu Vardhan Singh, Sujeet Guleria, Randeep Bhargava, Balram Indian J Med Res Original Article BACKGROUND & OBJECTIVES: India witnessed a massive second surge of COVID-19 cases since March 2021 after a period of decline from September 2020. Data collected under the National Clinical Registry for COVID-19 (NCRC) were analysed to describe the differences in demographic and clinical features of COVID-19 patients recruited during these two successive waves. METHODS: The NCRC, launched in September 2020, is an ongoing multicentre observational initiative, which provided the platform for the current investigation. Demographic, clinical, treatment and outcome data of hospitalized, confirmed COVID-19 patients were captured in an electronic data portal from 41 hospitals across India. Patients enrolled during September 1, 2020 to January 31, 2021 and February 1 to May 11, 2021 constituted participants of the two successive waves, respectively. RESULTS: As on May 11, 2021, 18961 individuals were recruited in the registry, 12059 and 6903 reflecting in-patients from the first and second waves, respectively. Mean age of the patients was significantly lower in the second wave [48.7 (18.1) yr vs. 50.7 (18.0) yr, P<0.001] with higher proportion of patients in the younger age group intervals of <20, and 20-39 yr. Approximately 70 per cent of the admitted patients were ≥ 40 yr of age in both waves of the pandemic. The proportion of males were slightly lower in second wave as compared to the first [4400 (63.7%) vs. 7886 (65.4%), P=0.02]. Commonest presenting symptom was fever in both waves. In the second wave, a significantly higher proportion [2625 (48.6%) vs. 4420 (42.8%), P<0.003] complained of shortness of breath, developed ARDS [422(13%) vs. 880 (7.9%), P<0.001], required supplemental oxygen [1637 (50.3%) vs. 4771 (42.7%), P<0.001], and mechanical ventilation [260 (15.9%) vs. 530 (11.1%), P<0.001]. Mortality also significantly increased in the second wave [OR: 1.35 (95% CI: 1.19, 1.52)] in all age groups except in <20 yr. INTERPRETATION & CONCLUSIONS: The second wave of COVID-19 in India was slightly different in presentation than the first wave, with a younger demography, lesser comorbidities, and presentation with breathlessness in greater frequency. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8555588/ /pubmed/34259194 http://dx.doi.org/10.4103/ijmr.ijmr_1628_21 Text en Copyright: © 2021 Indian Journal of Medical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kumar, Gunjan
Mukherjee, Aparna
Sharma, Ravendra K.
Menon, Geetha R.
Sahu, Damodar
Wig, Naveet
Panda, Samiran
Rao, Vishnu Vardhan
Singh, Sujeet
Guleria, Randeep
Bhargava, Balram
Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study
title Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study
title_full Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study
title_fullStr Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study
title_full_unstemmed Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study
title_short Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study
title_sort clinical profile of hospitalized covid-19 patients in first & second wave of the pandemic: insights from an indian registry based observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555588/
https://www.ncbi.nlm.nih.gov/pubmed/34259194
http://dx.doi.org/10.4103/ijmr.ijmr_1628_21
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