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The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome

BACKGROUND: Many patients with hypermobile Ehlers-Danlos Syndrome (EDS) suffer from cervical dystonia. Intramuscular injection of botulinum toxin may exacerbate myeloradiculopathy or atlantoaxial subluxation in this patient population. CASE: Three patients with hypermobile EDS underwent low-dose Ona...

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Detalles Bibliográficos
Autores principales: Wang, Tina J., Stecco, Antonio, Dashtipour, Khashayar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555620/
https://www.ncbi.nlm.nih.gov/pubmed/34754601
http://dx.doi.org/10.5334/tohm.647
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author Wang, Tina J.
Stecco, Antonio
Dashtipour, Khashayar
author_facet Wang, Tina J.
Stecco, Antonio
Dashtipour, Khashayar
author_sort Wang, Tina J.
collection PubMed
description BACKGROUND: Many patients with hypermobile Ehlers-Danlos Syndrome (EDS) suffer from cervical dystonia. Intramuscular injection of botulinum toxin may exacerbate myeloradiculopathy or atlantoaxial subluxation in this patient population. CASE: Three patients with hypermobile EDS underwent low-dose OnabotulinumtoxinA injections for cervical dystonia into myofascial sites selected using Fascial Manipulation diagnostic sequencing technique. All patients improved in clinical symptoms without complications. RESULTS: Patients clinically improved on the TWSTRS by 16 points with demonstrated changes in deep fascia thickness decrease of 0.28 mm. DISCUSSION: Low-dose OnabotulinumtoxinA injections into carefully selected sites is a safe and effective treatment in hypermobile EDS patients suffering from cervical dystonia.
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spelling pubmed-85556202021-11-08 The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome Wang, Tina J. Stecco, Antonio Dashtipour, Khashayar Tremor Other Hyperkinet Mov (N Y) Case Report BACKGROUND: Many patients with hypermobile Ehlers-Danlos Syndrome (EDS) suffer from cervical dystonia. Intramuscular injection of botulinum toxin may exacerbate myeloradiculopathy or atlantoaxial subluxation in this patient population. CASE: Three patients with hypermobile EDS underwent low-dose OnabotulinumtoxinA injections for cervical dystonia into myofascial sites selected using Fascial Manipulation diagnostic sequencing technique. All patients improved in clinical symptoms without complications. RESULTS: Patients clinically improved on the TWSTRS by 16 points with demonstrated changes in deep fascia thickness decrease of 0.28 mm. DISCUSSION: Low-dose OnabotulinumtoxinA injections into carefully selected sites is a safe and effective treatment in hypermobile EDS patients suffering from cervical dystonia. Ubiquity Press 2021-10-25 /pmc/articles/PMC8555620/ /pubmed/34754601 http://dx.doi.org/10.5334/tohm.647 Text en Copyright: © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Wang, Tina J.
Stecco, Antonio
Dashtipour, Khashayar
The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome
title The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome
title_full The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome
title_fullStr The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome
title_full_unstemmed The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome
title_short The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome
title_sort effect of low dose onabotulinumtoxina on cervical dystonia in hypermobile ehlers-danlos syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555620/
https://www.ncbi.nlm.nih.gov/pubmed/34754601
http://dx.doi.org/10.5334/tohm.647
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