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AS1411-functionalized delivery nanosystems for targeted cancer therapy

Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal t...

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Autores principales: Kozani, Pooria Safarzadeh, Kozani, Pouya Safarzadeh, Malik, Mohammad Tariq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555908/
https://www.ncbi.nlm.nih.gov/pubmed/34723284
http://dx.doi.org/10.37349/emed.2021.00039
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author Kozani, Pooria Safarzadeh
Kozani, Pouya Safarzadeh
Malik, Mohammad Tariq
author_facet Kozani, Pooria Safarzadeh
Kozani, Pouya Safarzadeh
Malik, Mohammad Tariq
author_sort Kozani, Pooria Safarzadeh
collection PubMed
description Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal target for the treatment of various cancers. AS1411 is a synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows a considerably high affinity for NCL, therefore, being capable of inducing growth inhibition in a variety of tumor cells. The high affinity and specificity of AS1411 towards NCL make it a suitable targeting tool, which can be used for the functionalization of therapeutic payloaddelivery nanosystems to selectively target tumor cells. This review explores the advances in NCL-targeting cancer therapy through AS1411-functionalized delivery nanosystems for the selective delivery of a broad spectrum of therapeutic agents.
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spelling pubmed-85559082021-10-29 AS1411-functionalized delivery nanosystems for targeted cancer therapy Kozani, Pooria Safarzadeh Kozani, Pouya Safarzadeh Malik, Mohammad Tariq Explor Med Article Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal target for the treatment of various cancers. AS1411 is a synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows a considerably high affinity for NCL, therefore, being capable of inducing growth inhibition in a variety of tumor cells. The high affinity and specificity of AS1411 towards NCL make it a suitable targeting tool, which can be used for the functionalization of therapeutic payloaddelivery nanosystems to selectively target tumor cells. This review explores the advances in NCL-targeting cancer therapy through AS1411-functionalized delivery nanosystems for the selective delivery of a broad spectrum of therapeutic agents. 2021-04-30 2021 /pmc/articles/PMC8555908/ /pubmed/34723284 http://dx.doi.org/10.37349/emed.2021.00039 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Kozani, Pooria Safarzadeh
Kozani, Pouya Safarzadeh
Malik, Mohammad Tariq
AS1411-functionalized delivery nanosystems for targeted cancer therapy
title AS1411-functionalized delivery nanosystems for targeted cancer therapy
title_full AS1411-functionalized delivery nanosystems for targeted cancer therapy
title_fullStr AS1411-functionalized delivery nanosystems for targeted cancer therapy
title_full_unstemmed AS1411-functionalized delivery nanosystems for targeted cancer therapy
title_short AS1411-functionalized delivery nanosystems for targeted cancer therapy
title_sort as1411-functionalized delivery nanosystems for targeted cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555908/
https://www.ncbi.nlm.nih.gov/pubmed/34723284
http://dx.doi.org/10.37349/emed.2021.00039
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