Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity

Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson’s disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by lentiviral-med...

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Detalles Bibliográficos
Autores principales: Bido, Simone, Muggeo, Sharon, Massimino, Luca, Marzi, Matteo Jacopo, Giannelli, Serena Gea, Melacini, Elena, Nannoni, Melania, Gambarè, Diana, Bellini, Edoardo, Ordazzo, Gabriele, Rossi, Greta, Maffezzini, Camilla, Iannelli, Angelo, Luoni, Mirko, Bacigaluppi, Marco, Gregori, Silvia, Nicassio, Francesco, Broccoli, Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556263/
https://www.ncbi.nlm.nih.gov/pubmed/34716339
http://dx.doi.org/10.1038/s41467-021-26519-x

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