Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Circular tandem repeat proteins (‘cTRPs’) are de novo designed protein scaffolds (in this and prior studies, based on antiparallel two-helix bundles) that contain repeated protein sequences and structural motifs and form closed circular structures. They can display significant stability and solubili...

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Detalles Bibliográficos
Autores principales: Hallinan, Jazmine P., Doyle, Lindsey A., Shen, Betty W., Gewe, Mesfin M., Takushi, Brittany, Kennedy, Madison A., Friend, Della, Roberts, James M., Bradley, Philip, Stoddard, Barry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556268/
https://www.ncbi.nlm.nih.gov/pubmed/34716407
http://dx.doi.org/10.1038/s42003-021-02766-y

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