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Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556284/ https://www.ncbi.nlm.nih.gov/pubmed/34716350 http://dx.doi.org/10.1038/s41467-021-26551-x |
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| author | Lin, Wei-Yu Fordham, Sarah E. Hungate, Eric Sunter, Nicola J. Elstob, Claire Xu, Yaobo Park, Catherine Quante, Anne Strauch, Konstantin Gieger, Christian Skol, Andrew Rahman, Thahira Sucheston-Campbell, Lara Wang, Junke Hahn, Theresa Clay-Gilmour, Alyssa I. Jones, Gail L. Marr, Helen J. Jackson, Graham H. Menne, Tobias Collin, Mathew Ivey, Adam Hills, Robert K. Burnett, Alan K. Russell, Nigel H. Fitzgibbon, Jude Larson, Richard A. Le Beau, Michelle M. Stock, Wendy Heidenreich, Olaf Alharbi, Abrar Allsup, David J. Houlston, Richard S. Norden, Jean Dickinson, Anne M. Douglas, Elisabeth Lendrem, Clare Daly, Ann K. Palm, Louise Piechocki, Kim Jeffries, Sally Bornhäuser, Martin Röllig, Christoph Altmann, Heidi Ruhnke, Leo Kunadt, Desiree Wagenführ, Lisa Cordell, Heather J. Darlay, Rebecca Andersen, Mette K. Fontana, Maria C. Martinelli, Giovanni Marconi, Giovanni Sanz, Miguel A. Cervera, José Gómez-Seguí, Inés Cluzeau, Thomas Moreilhon, Chimène Raynaud, Sophie Sill, Heinz Voso, Maria Teresa Lo-Coco, Francesco Dombret, Hervé Cheok, Meyling Preudhomme, Claude Gale, Rosemary E. Linch, David Gaal-Wesinger, Julia Masszi, Andras Nowak, Daniel Hofmann, Wolf-Karsten Gilkes, Amanda Porkka, Kimmo Milosevic Feenstra, Jelena D. Kralovics, Robert Grimwade, David Meggendorfer, Manja Haferlach, Torsten Krizsán, Szilvia Bödör, Csaba Stölzel, Friedrich Onel, Kenan Allan, James M. |
| author_facet | Lin, Wei-Yu Fordham, Sarah E. Hungate, Eric Sunter, Nicola J. Elstob, Claire Xu, Yaobo Park, Catherine Quante, Anne Strauch, Konstantin Gieger, Christian Skol, Andrew Rahman, Thahira Sucheston-Campbell, Lara Wang, Junke Hahn, Theresa Clay-Gilmour, Alyssa I. Jones, Gail L. Marr, Helen J. Jackson, Graham H. Menne, Tobias Collin, Mathew Ivey, Adam Hills, Robert K. Burnett, Alan K. Russell, Nigel H. Fitzgibbon, Jude Larson, Richard A. Le Beau, Michelle M. Stock, Wendy Heidenreich, Olaf Alharbi, Abrar Allsup, David J. Houlston, Richard S. Norden, Jean Dickinson, Anne M. Douglas, Elisabeth Lendrem, Clare Daly, Ann K. Palm, Louise Piechocki, Kim Jeffries, Sally Bornhäuser, Martin Röllig, Christoph Altmann, Heidi Ruhnke, Leo Kunadt, Desiree Wagenführ, Lisa Cordell, Heather J. Darlay, Rebecca Andersen, Mette K. Fontana, Maria C. Martinelli, Giovanni Marconi, Giovanni Sanz, Miguel A. Cervera, José Gómez-Seguí, Inés Cluzeau, Thomas Moreilhon, Chimène Raynaud, Sophie Sill, Heinz Voso, Maria Teresa Lo-Coco, Francesco Dombret, Hervé Cheok, Meyling Preudhomme, Claude Gale, Rosemary E. Linch, David Gaal-Wesinger, Julia Masszi, Andras Nowak, Daniel Hofmann, Wolf-Karsten Gilkes, Amanda Porkka, Kimmo Milosevic Feenstra, Jelena D. Kralovics, Robert Grimwade, David Meggendorfer, Manja Haferlach, Torsten Krizsán, Szilvia Bödör, Csaba Stölzel, Friedrich Onel, Kenan Allan, James M. |
| author_sort | Lin, Wei-Yu |
| collection | PubMed |
| description | Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10(−8); KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10(−10); HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA). |
| format | Online Article Text |
| id | pubmed-8556284 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85562842021-11-15 Genome-wide association study identifies susceptibility loci for acute myeloid leukemia Lin, Wei-Yu Fordham, Sarah E. Hungate, Eric Sunter, Nicola J. Elstob, Claire Xu, Yaobo Park, Catherine Quante, Anne Strauch, Konstantin Gieger, Christian Skol, Andrew Rahman, Thahira Sucheston-Campbell, Lara Wang, Junke Hahn, Theresa Clay-Gilmour, Alyssa I. Jones, Gail L. Marr, Helen J. Jackson, Graham H. Menne, Tobias Collin, Mathew Ivey, Adam Hills, Robert K. Burnett, Alan K. Russell, Nigel H. Fitzgibbon, Jude Larson, Richard A. Le Beau, Michelle M. Stock, Wendy Heidenreich, Olaf Alharbi, Abrar Allsup, David J. Houlston, Richard S. Norden, Jean Dickinson, Anne M. Douglas, Elisabeth Lendrem, Clare Daly, Ann K. Palm, Louise Piechocki, Kim Jeffries, Sally Bornhäuser, Martin Röllig, Christoph Altmann, Heidi Ruhnke, Leo Kunadt, Desiree Wagenführ, Lisa Cordell, Heather J. Darlay, Rebecca Andersen, Mette K. Fontana, Maria C. Martinelli, Giovanni Marconi, Giovanni Sanz, Miguel A. Cervera, José Gómez-Seguí, Inés Cluzeau, Thomas Moreilhon, Chimène Raynaud, Sophie Sill, Heinz Voso, Maria Teresa Lo-Coco, Francesco Dombret, Hervé Cheok, Meyling Preudhomme, Claude Gale, Rosemary E. Linch, David Gaal-Wesinger, Julia Masszi, Andras Nowak, Daniel Hofmann, Wolf-Karsten Gilkes, Amanda Porkka, Kimmo Milosevic Feenstra, Jelena D. Kralovics, Robert Grimwade, David Meggendorfer, Manja Haferlach, Torsten Krizsán, Szilvia Bödör, Csaba Stölzel, Friedrich Onel, Kenan Allan, James M. Nat Commun Article Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10(−8); KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10(−10); HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA). Nature Publishing Group UK 2021-10-29 /pmc/articles/PMC8556284/ /pubmed/34716350 http://dx.doi.org/10.1038/s41467-021-26551-x Text en © The Author(s) 2021, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Lin, Wei-Yu Fordham, Sarah E. Hungate, Eric Sunter, Nicola J. Elstob, Claire Xu, Yaobo Park, Catherine Quante, Anne Strauch, Konstantin Gieger, Christian Skol, Andrew Rahman, Thahira Sucheston-Campbell, Lara Wang, Junke Hahn, Theresa Clay-Gilmour, Alyssa I. Jones, Gail L. Marr, Helen J. Jackson, Graham H. Menne, Tobias Collin, Mathew Ivey, Adam Hills, Robert K. Burnett, Alan K. Russell, Nigel H. Fitzgibbon, Jude Larson, Richard A. Le Beau, Michelle M. Stock, Wendy Heidenreich, Olaf Alharbi, Abrar Allsup, David J. Houlston, Richard S. Norden, Jean Dickinson, Anne M. Douglas, Elisabeth Lendrem, Clare Daly, Ann K. Palm, Louise Piechocki, Kim Jeffries, Sally Bornhäuser, Martin Röllig, Christoph Altmann, Heidi Ruhnke, Leo Kunadt, Desiree Wagenführ, Lisa Cordell, Heather J. Darlay, Rebecca Andersen, Mette K. Fontana, Maria C. Martinelli, Giovanni Marconi, Giovanni Sanz, Miguel A. Cervera, José Gómez-Seguí, Inés Cluzeau, Thomas Moreilhon, Chimène Raynaud, Sophie Sill, Heinz Voso, Maria Teresa Lo-Coco, Francesco Dombret, Hervé Cheok, Meyling Preudhomme, Claude Gale, Rosemary E. Linch, David Gaal-Wesinger, Julia Masszi, Andras Nowak, Daniel Hofmann, Wolf-Karsten Gilkes, Amanda Porkka, Kimmo Milosevic Feenstra, Jelena D. Kralovics, Robert Grimwade, David Meggendorfer, Manja Haferlach, Torsten Krizsán, Szilvia Bödör, Csaba Stölzel, Friedrich Onel, Kenan Allan, James M. Genome-wide association study identifies susceptibility loci for acute myeloid leukemia |
| title | Genome-wide association study identifies susceptibility loci for acute myeloid leukemia |
| title_full | Genome-wide association study identifies susceptibility loci for acute myeloid leukemia |
| title_fullStr | Genome-wide association study identifies susceptibility loci for acute myeloid leukemia |
| title_full_unstemmed | Genome-wide association study identifies susceptibility loci for acute myeloid leukemia |
| title_short | Genome-wide association study identifies susceptibility loci for acute myeloid leukemia |
| title_sort | genome-wide association study identifies susceptibility loci for acute myeloid leukemia |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556284/ https://www.ncbi.nlm.nih.gov/pubmed/34716350 http://dx.doi.org/10.1038/s41467-021-26551-x |
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