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Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse

Driver gene mutations that are more prevalent in metastatic, castration-resistant prostate cancer (mCRPC) than localized disease represent candidate prognostic biomarkers. We analyze 1,844 localized (1,289) or mCRPC (555) tumors and quantify the prevalence of 113 somatic driver single nucleotide var...

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Detalles Bibliográficos
Autores principales:	Fraser, Michael, Livingstone, Julie, Wrana, Jeffrey L., Finelli, Antonio, He, Housheng Hansen, van der Kwast, Theodorus, Zlotta, Alexandre R., Bristow, Robert G., Boutros, Paul C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556363/ https://www.ncbi.nlm.nih.gov/pubmed/34716314 http://dx.doi.org/10.1038/s41467-021-26489-0

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