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Is dyslipidemia associated to mortality in patients with COVID-19?
BACKGROUND: The COVID-19 pandemic has affected millions of people worldwide, so it is necessary to determine risk factors associated with severe disease and mortality, to make a risk stratification for the appropriate use of hospital resources. Except for a few cases, most deaths from this disease a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Mosby, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556495/ http://dx.doi.org/10.1016/j.ahj.2021.10.029 |
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author | Grecia, Celis Guillermo, Arauz Eduardo, Camey Alejandra, Cárcamo |
author_facet | Grecia, Celis Guillermo, Arauz Eduardo, Camey Alejandra, Cárcamo |
author_sort | Grecia, Celis |
collection | PubMed |
description | BACKGROUND: The COVID-19 pandemic has affected millions of people worldwide, so it is necessary to determine risk factors associated with severe disease and mortality, to make a risk stratification for the appropriate use of hospital resources. Except for a few cases, most deaths from this disease are related to the patient's comorbidities. Several observational studies have reported an association between dyslipidemia and the risk of severe COVID-19 disease, but there is no consensus. Objective: The present study aimed to determine whether there is an association between dyslipidemia and mortality in patients with COVID-19. METHODS: Lipid profiles were performed in 200 Guatemalan patients with COVID-19 admitted to the Intensive Care Unit of the Guatemalan Institute of Social Security, between May and June 2021, and they were followed up to determine their discharge condition (deceased or recovered). RESULTS: To determine the normality of the sample, the Kolmogorov-Smirnov statistic was used, followed by logistic regression to determine if there was an association between mortality and the following variables: dyslipidemia (p=0.224), total cholesterol (p=0.114), triglycerides (0.831) Conclusions: Although there are studies that prove an association between dyslipidemia and mortality due to COVID-19, in our study we did not find the same, therefore it is necessary to perform more studies to reach a consensus. |
format | Online Article Text |
id | pubmed-8556495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Published by Mosby, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85564952021-11-01 Is dyslipidemia associated to mortality in patients with COVID-19? Grecia, Celis Guillermo, Arauz Eduardo, Camey Alejandra, Cárcamo Am Heart J 0037 BACKGROUND: The COVID-19 pandemic has affected millions of people worldwide, so it is necessary to determine risk factors associated with severe disease and mortality, to make a risk stratification for the appropriate use of hospital resources. Except for a few cases, most deaths from this disease are related to the patient's comorbidities. Several observational studies have reported an association between dyslipidemia and the risk of severe COVID-19 disease, but there is no consensus. Objective: The present study aimed to determine whether there is an association between dyslipidemia and mortality in patients with COVID-19. METHODS: Lipid profiles were performed in 200 Guatemalan patients with COVID-19 admitted to the Intensive Care Unit of the Guatemalan Institute of Social Security, between May and June 2021, and they were followed up to determine their discharge condition (deceased or recovered). RESULTS: To determine the normality of the sample, the Kolmogorov-Smirnov statistic was used, followed by logistic regression to determine if there was an association between mortality and the following variables: dyslipidemia (p=0.224), total cholesterol (p=0.114), triglycerides (0.831) Conclusions: Although there are studies that prove an association between dyslipidemia and mortality due to COVID-19, in our study we did not find the same, therefore it is necessary to perform more studies to reach a consensus. Published by Mosby, Inc. 2021-12 2021-10-30 /pmc/articles/PMC8556495/ http://dx.doi.org/10.1016/j.ahj.2021.10.029 Text en Copyright © 2021 Published by Mosby, Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | 0037 Grecia, Celis Guillermo, Arauz Eduardo, Camey Alejandra, Cárcamo Is dyslipidemia associated to mortality in patients with COVID-19? |
title | Is dyslipidemia associated to mortality in patients with COVID-19? |
title_full | Is dyslipidemia associated to mortality in patients with COVID-19? |
title_fullStr | Is dyslipidemia associated to mortality in patients with COVID-19? |
title_full_unstemmed | Is dyslipidemia associated to mortality in patients with COVID-19? |
title_short | Is dyslipidemia associated to mortality in patients with COVID-19? |
title_sort | is dyslipidemia associated to mortality in patients with covid-19? |
topic | 0037 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556495/ http://dx.doi.org/10.1016/j.ahj.2021.10.029 |
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