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COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study
AIM: Healthcare personnel (HCP) are prioritized for coronavirus disease 2019 (COVID-19) vaccination to protect them and non-disruptive provision of healthcare services. We assessed the impact of the Pfizer-BioNTech vaccine on morbidity and absenteeism among HCP. METHODS: We studied 7445 HCP in five...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556541/ https://www.ncbi.nlm.nih.gov/pubmed/34740473 http://dx.doi.org/10.1016/j.vaccine.2021.10.054 |
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author | Maltezou, Helena C. Panagopoulos, Periklis Sourri, Flora Giannouchos, Theodoros V. Raftopoulos, Vasilios Gamaletsou, Maria N. Karapanou, Amalia Koukou, Dimitra-Maria Koutsidou, Athanasia Peskelidou, Emmanuela Papanastasiou, Konstantina Souliotis, Kyriakos Lourida, Athanasia Sipsas, Nikolaos V. Hatzigeorgiou, Dimitrios |
author_facet | Maltezou, Helena C. Panagopoulos, Periklis Sourri, Flora Giannouchos, Theodoros V. Raftopoulos, Vasilios Gamaletsou, Maria N. Karapanou, Amalia Koukou, Dimitra-Maria Koutsidou, Athanasia Peskelidou, Emmanuela Papanastasiou, Konstantina Souliotis, Kyriakos Lourida, Athanasia Sipsas, Nikolaos V. Hatzigeorgiou, Dimitrios |
author_sort | Maltezou, Helena C. |
collection | PubMed |
description | AIM: Healthcare personnel (HCP) are prioritized for coronavirus disease 2019 (COVID-19) vaccination to protect them and non-disruptive provision of healthcare services. We assessed the impact of the Pfizer-BioNTech vaccine on morbidity and absenteeism among HCP. METHODS: We studied 7445 HCP in five tertiary-care hospitals in Greece from November 15, 2020 through April 18, 2021. RESULTS: A total of 910 episodes of absenteeism and 9695 days of absence were recorded during the entire study period. Starting from January 4, 2021, 4823/7445 HCP (64.8%) were fully or partially vaccinated. Overall, 535 episodes of absenteeism occurred from January 4, 2021 through April 18, 2021, including 309 (57.76%) episodes among 2622 unvaccinated HCP and 226 (42.24%) episodes among 4823 vaccinated HCP (11.8 versus 4.7 episodes of absenteeism per 100 HCP, respectively; p-value < 0.001). The mean duration of absenteeism was 11.9 days among unvaccinated HCP compared with 6.9 days among vaccinated HCP (p-value < 0.001). Unvaccinated HCP more frequently developed acute respiratory infection, influenza-like illness, and COVID-19 (p-values < 0.001 for all comparisons). Vaccine effectiveness for fully vaccinated HCP was estimated at 94.16% [confidence interval (CI): 88.50%-98.05%) against COVID-19, 83.62% (CI: 73.36%-90.38%) against SARS-CoV-2 infection (asymptomatic or COVID-19), and 66.42% (CI: 56.86%-74.15%) against absenteeism. CONCLUSION: The COVID-19 pandemic had a considerable impact on healthcare workforce. The Pfizer-BioNTech vaccine significantly reduced morbidity, COVID-19, absenteeism and duration of absenteeism among HCP during a period of high SARS-CoV-2 circulation in the community. It is expected that HCP vaccination will protect them and healthcare services and contain healthcare costs. |
format | Online Article Text |
id | pubmed-8556541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85565412021-11-01 COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study Maltezou, Helena C. Panagopoulos, Periklis Sourri, Flora Giannouchos, Theodoros V. Raftopoulos, Vasilios Gamaletsou, Maria N. Karapanou, Amalia Koukou, Dimitra-Maria Koutsidou, Athanasia Peskelidou, Emmanuela Papanastasiou, Konstantina Souliotis, Kyriakos Lourida, Athanasia Sipsas, Nikolaos V. Hatzigeorgiou, Dimitrios Vaccine Article AIM: Healthcare personnel (HCP) are prioritized for coronavirus disease 2019 (COVID-19) vaccination to protect them and non-disruptive provision of healthcare services. We assessed the impact of the Pfizer-BioNTech vaccine on morbidity and absenteeism among HCP. METHODS: We studied 7445 HCP in five tertiary-care hospitals in Greece from November 15, 2020 through April 18, 2021. RESULTS: A total of 910 episodes of absenteeism and 9695 days of absence were recorded during the entire study period. Starting from January 4, 2021, 4823/7445 HCP (64.8%) were fully or partially vaccinated. Overall, 535 episodes of absenteeism occurred from January 4, 2021 through April 18, 2021, including 309 (57.76%) episodes among 2622 unvaccinated HCP and 226 (42.24%) episodes among 4823 vaccinated HCP (11.8 versus 4.7 episodes of absenteeism per 100 HCP, respectively; p-value < 0.001). The mean duration of absenteeism was 11.9 days among unvaccinated HCP compared with 6.9 days among vaccinated HCP (p-value < 0.001). Unvaccinated HCP more frequently developed acute respiratory infection, influenza-like illness, and COVID-19 (p-values < 0.001 for all comparisons). Vaccine effectiveness for fully vaccinated HCP was estimated at 94.16% [confidence interval (CI): 88.50%-98.05%) against COVID-19, 83.62% (CI: 73.36%-90.38%) against SARS-CoV-2 infection (asymptomatic or COVID-19), and 66.42% (CI: 56.86%-74.15%) against absenteeism. CONCLUSION: The COVID-19 pandemic had a considerable impact on healthcare workforce. The Pfizer-BioNTech vaccine significantly reduced morbidity, COVID-19, absenteeism and duration of absenteeism among HCP during a period of high SARS-CoV-2 circulation in the community. It is expected that HCP vaccination will protect them and healthcare services and contain healthcare costs. Elsevier Ltd. 2021-11-26 2021-10-30 /pmc/articles/PMC8556541/ /pubmed/34740473 http://dx.doi.org/10.1016/j.vaccine.2021.10.054 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Maltezou, Helena C. Panagopoulos, Periklis Sourri, Flora Giannouchos, Theodoros V. Raftopoulos, Vasilios Gamaletsou, Maria N. Karapanou, Amalia Koukou, Dimitra-Maria Koutsidou, Athanasia Peskelidou, Emmanuela Papanastasiou, Konstantina Souliotis, Kyriakos Lourida, Athanasia Sipsas, Nikolaos V. Hatzigeorgiou, Dimitrios COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study |
title | COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study |
title_full | COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study |
title_fullStr | COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study |
title_full_unstemmed | COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study |
title_short | COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study |
title_sort | covid-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: a prospective multicenter study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556541/ https://www.ncbi.nlm.nih.gov/pubmed/34740473 http://dx.doi.org/10.1016/j.vaccine.2021.10.054 |
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